Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1988-06-08
1991-10-29
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514 23, 514 24, 514 40, 562554, A01N 3712, A01N 4304
Patent
active
050617290
ABSTRACT:
The invention relates to pharmaceutical compositions as well as the preparation thereof which are useful for improving the status of patients suffering from external otitis or otitis (otitis media), or particularly from a chronic otitis (otitis media chronica). The pharmaceutical compositions according to the invention contain a sulfhydryl-containing compound, an antibacterial chemotherapeutic agent, an aspecific antiinflammatory agent and optionally a kerotolytic agent. The compositions preferably contain N-acetyl-L-cysteine as sulfhydryl-containing compound.
REFERENCES:
patent: 3091569 (1963-05-01), Sheffner
Martindale, 28th Ed. (1982), pp. 49-50, and 644-645.
The Merck Manual, 14th Ed. (1982), pp. 1944-1955.
Tabachnik et al., "Studies on the Reduction of Sputum Viscosity in Cystic Fibrosis Using an Orally Absorbed Protected Thiol", J. Pharmacol. Exp. Ther. 214: 246-249, 1980.
Tobradex Package Insert, Alcon Labs.
Decadron Package Insert, Merck, Sharp and Dome.
Facts and Comparisons, Mar. 1988 update, pp. 493-497, 518-520a.
Rote Liste, 1979, pp. 177-178, No. 23, 177B, Editio Cantor, Aulendorf, Federal Republic of Germany, Fluimucil Antibiotic (The whole abstract).
Nebramycin, A New Broad Spectrum Antibiotic Complex, Wick, W. E. et al., Antimicrobial Agents and Chemotherapy, pp. 341-348 (1968).
Handbook of Common Drugs, pp. 7510, 7556 (Chinese).
The In Vitro Reduction of Viscosity of Human Tracheobronchial Secretions by Acetylcysteine, A. L. Sheffner et al., Am. Rev. Respir. Dis. 90, pp. 721-729 (1964).
Merck Index, 10th Edition, Compound 82.
Safety and Drug Interactions of Oral Acetylcysteine Related to Utilization Data, V. Ferrari, Eur. J. Respir. Dis. 1980, vol. 61, Suppl., pp. 151-157.
Effect of N-Acetylcysteine on Antibiotic Activity and Bacterial Growth in Vitro, Michael F. Parry et al., J. Clinical Microbiol., vol. 5, No. 1, pp. 58-61 (Jan. 1977).
Bacsa Gyorgy
Barna nee Katona Klara
Katona nee Lendvay Agnes
Kincses Gyula
Kocsar Barna
Biogal Gyogyszergyar
Criares T. J.
Dubno Herbert
Goldberg Jerome D.
Myers Jonathan
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