Pharmaceutical composition and method of use

Details Pharmaceutical composition and method of use Pharmaceutical composition and method of use

1989-06-09

1992-09-08

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514456, 536 41, 536 181, A61K 3135, A61K 3170

Patent

active

051458390

ABSTRACT:
Naringin and naringenin are disclosed as pharmaceuticals that selectively inhibit the growth of cancer cells in the presence of normal cells. They are also effective against cancer cells that are resistant to chemotherapy or radiotherapy. It is shown that naringin and naringenin selectively contract DNA chains of tumor cells but not DNA chains of normal cells. The subject compounds also exhibit anti-viral activity. A novel method for the recovery of naringin and naringenin from natural vegetable sources is taught.

REFERENCES:
patent: 3903266 (1975-09-01), Robbins
patent: 4238483 (1980-12-01), Frazier
patent: 4264729 (1981-04-01), Beljanski
patent: 4297348 (1981-10-01), Frazier
Suolinna et al.; Cancer Research, 35(7):1865-1872 (1975).
Takase et al.; Chemical Abstracts, 109(1):810h (1987).
Ono et al.; Eur. J. Biochem., 190:469-476, (Jul. 5, 1990).

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