Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-01-22
1987-08-11
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 3133
Patent
active
046862153
ABSTRACT:
The pharmaceutical composition possessing antitumor activity against tumors susceptible to 2-carbamoylaziridine which consists of a therapeutically efficaceous quantity of 1-H-2-aziridinecarbonic acid derivative having the formula ##STR1## where R is NH.sub.2 and a pharmaceutically suitable solvent or filler. The pharmaceutical composition possesses a high activity against tumors susceptible to 2-carbamoylaziridine, a wide spectrum of antitumor effect and low toxicity (LD.sub.50 within the range of 3,000 and 3,500 mg/kg. The invention is also a method for treating malignant tumors susceptible to 2-carbamoxylaziridine by administration of 2-carbamoyl-aziridine.
REFERENCES:
Chemical Abstracts 59: 11424(b) (1967).
Chemical Abstracts 70: 10608(p) (1969).
Carter et al., Chemotherapy of Cancer, 2nd ed., a Wiley Medical Publication, N.Y., N.Y., 1981, pp. 26-43.
Astapenok Elena B.
Kalvinsh Ivars Y.
Goldberg Jerome D.
Institut Organicheskogo Sinteza Akademii Nauk SSR
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