Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1994-11-02
1997-04-15
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514395, A61K 3155, A61K 31415
Patent
active
056209754
ABSTRACT:
Pharmaceutical composition comprising a tetrahydronaphthalene derivative of the formula ##STR1## wherein R.sup.1 is halogen, R.sup.2 is lower-alkoxy-lower-alkylcarbonyloxy, X is C.sub.2 -C.sub.8 -alkylene and A is benzimidazolyl optionally substituted at the N atom by alkyl with 1 to 12 C atoms,
and a pyridazodiazepine of the formula ##STR2## wherein R.sup.4 is aralkyl with 1 to 6 C atoms in the alkyl residue and phenyl, which is optionally mono-substituted by halogen, alkoxy with 1 to 6 C atoms or phenyl, as the aryl residue, R.sup.5 and R.sup.6 each independently are hydrogen or alkyl with 1 to 6 C atoms and R.sup.7 and R.sup.8 each are hydrogen or together are an oxo group,
in the form of their free bases, their hydrates or their pharmaceutically usable salts for the simultaneous, separate or planned stepwise use in the control or prevention of circulatory disorders, especially hypertension.
REFERENCES:
patent: 4658024 (1987-04-01), Attwood et al.
patent: 4808605 (1989-02-01), Branca et al.
patent: 4859665 (1989-08-01), Garthoff et al.
patent: 4871731 (1989-10-01), Walker
patent: 4983598 (1991-01-01), Cavero et al.
patent: 5110813 (1992-05-01), Grupp et al.
Clozel et al., Cardiovasc. Drug Rev. 9, 4-17 (1991).
Hypertension, 9, 178-187 (1987).
J.Cardiovasc.Pharmacol. 7, 588-591 (1985).
Arzneimittelforschung Bd. 40, Nr. 4, 417-421, 1990.
Clozel Jean-Paul
M uller Rita
Osterrieder Wolfgang
Ciambrone Coletti Ellen
Hoffmann-La Roche Inc.
Johnston George W.
Jordan Kimberly
Moezie M.
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