Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Animal or plant cell
Patent
1993-03-02
1995-09-26
Rollins, John W.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Animal or plant cell
128897, 128898, 128899, 424 931, 424 946, 424423, 424484, 424574, 435174, 435176, 435177, 435178, 435180, 435182, 43524022, 514909, A61B 1900, A01N 6302, C12N 1114, C12N 500
Patent
active
054532701
ABSTRACT:
There is disclosed a pharmaceutical composition and method for metabolic consumption of calories and weight loss. The pharmaceutical composition is a culture of brown adipose cells, preferably encapsulated in a porous growth matrix, and a semipermeable membrane encapsulating the porous matrix wherein the semipermeable membrane has a molecular weight cutoff of at least 10,000 daltons and, preferably, a lipoprotein lipase embedded therein. Further disclosed is a pharmaceutical composition for metabolizing fatty acids into carbon dioxide, water and heat including a mammalian cell stably transfected with a DNA sequence coding for a mammalian UCP polypeptide, wherein the transfected mammalian cell transcribes and translates UCP polypeptide. Also disclosed is a pharmaceutical composition for metabolizing fatty acids into carbon dioxide, water and heat including a cDNA sequence encoding a mammalian UCP sequence, wherein the cDNA sequence is taken up into a hosts cell, in vivo, and is translated into UCP polypeptide, causing uncoupling of oxidative metabolism. The present invention provides a pharmaceutical composition for metabolizing fatty acids into carbon dioxide, water and heat which includes a culture of allogeneic brown fat cells, wherein the brown fat cells are proliferated ex vivo.
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Hypermetabolic Therapies, Inc.
Oster Jeffrey B.
Rollins John W.
Ware Deborah K.
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