Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1996-10-11
1999-02-16
Huff, Sheela
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
424 931, 4241921, 424520, 514 12, 530324, A61K 3900
Patent
active
058717390
ABSTRACT:
A pharmaceutical composition comprising, as an active ingredient, a lens antigen which induces a lens cell damaging immune response or a microorganism capable of expressing a lens antigen which induces a lens cell damaging immune response. The pharmaceutical composition of the present invention containing, as an active ingredient, a lens antigen or a microorganism capable of expressing said antigen shows markedly superior inhibitory effects on the increase of an anti-lens protein antibody titer. Therefore, it most probably treats or prevents cataract effectively, and delays onset of cataract. Thus, the composition is extremely useful for cataract patients and reserve patients of cataract.
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Groenen et al Eur. J. Biochem. vol. 205 p. 671, 1992.
Chambers et al, J. Biol. Chem. vol. 266 p. 6742, Apr. 1991.
Hogg et al J. Biol. Chem. vol. 261 p. 12420, Sep. 1986.
I. Angunawela, "The effects of immunosuppression on the development of (experimental) cataract", Immunology, vol. 64, pp. 69-72, 1988.
Huff Sheela
Senju Pharmaceutical Co. Ltd.
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