Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1982-08-20
1985-04-16
Rosen, Sam
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514345, 514576, A61K 3514
Patent
active
045115575
ABSTRACT:
Compositions for increasing oxygen supply in tissue of warm-blooded animals comprising at least one vasoactive compound selected from the group consisting of (a) calcium 2,5-dihydroxy-phenylsulfonate, (b) a 3,7-dihydro-3,7-dialkyl-1H-purine-2,6-dione of the formula ##STR1## wherein AlK and AlK' are individually alkyl of 1 to 4 carbon atoms, n is an integer from 2 to 4 and R is selected from the group consisting of ##STR2## and --CH.sub.2 --CH.sub.3, (c) a pyrazolo-[3,4-d]pyrimidine of the formula ##STR3## wherein R.sup.1 and R.sup.2 are individually selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl of 2 to 8 carbon atoms and alkylcarbonylalkyl of 4 to 8 carbon atoms with the proviso that R.sup.1 and R.sup.2 are not both hydrogen and A is selected from the group consisting of ##STR4## wherein R.sup.3 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms and R.sup.4 is selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms and alkenyl of 2 to 6 carbon atoms, (d) a pyridone of the formula ##STR5## wherein m is an integer from 2 to 4 and R.sup.5 is selected from the group consisting of ##STR6## --CH.sub.2 --CH.sub.3 and --CH.sub.2 --CH.sub.2 --OH and (e) a compound selected from the group consisting of nicergoline, vincamine and dipyridamol and a potentiating amount of a dialyzed concentrate of deproteinized calf's blood with the blood constituents having a molecular weight less than 10,000 and method for increasing oxygen supply to animal tissues.
REFERENCES:
Stefanovich et al.--Chem. Abst. vol. 86 (1977) p. 37640k.
Steen et al.--Chem. Abst. vol. 95 (1981) p. 509j.
Muserlian Charles A.
Rosen Sam
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