Drug – bio-affecting and body treating compositions – Effervescent or pressurized fluid containing – Organic pressurized fluid
Patent
1997-05-27
1999-09-28
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Effervescent or pressurized fluid containing
Organic pressurized fluid
514 2, 514179, 514535, 514573, 514951, A61K 900, A61K 3800, A61K 3156, A61K 3124
Patent
active
059583797
DESCRIPTION:
BRIEF SUMMARY
The present invention is directed to a pharmaceutical composition with the characteristics of the generic part of patent claim 1.
Pharmaceutical compositions with the active substance mentioned in the main claim are usually formed as injectable composition or as tablets, dragees or suppositories, in order to guarantee that way that the respective active substance is transported to the site of action within a very short time by means of the corresponding body liquid, particularly by means of the blood, in order to systemically cause the desired effect.
Only in a few exceptional cases the active substances mentioned in the main claim are formed in the way that they can be topically applied, whereby such an application is suitable preferably for a local application, meaning for the locally limited external treatment. Rheumatic ointments with non-steroid anti-rheumatics or heparin-containing ointments or creams are for example known which, however, are locally applied to the infected body zones where they effect in a regionally limited way.
Herefore it is necessary to apply these ointments or creams to the regionally limited, infected or suffering body zone and to rub them in, which is often experienced as being painful when locally limited infections or injuries being sensitive to pressure are treated.
The initially mentioned systemically effective tablets, dragees, suppositories, injections or infusions cause essential problem when the patients have to be treated over a longer time period. Such problems, which do not depend on the active substance itself but on the afore described known applications, express themselves, for example, in stomach-ache, irritations of the anus and/or the intestines, or bruises from infusions or injections, or obliteration of veins, which sometimes leads to the fact that the form of application has to be changed or that the application of the respective active substance has even to be renounced on.
The present invention has the object of providing a pharmaceutical composition of the indicated sort, whereby this pharmaceutical composition is locally as well as systemically applicable in a particularly simple manner and highly effective.
This object is realised according to the invention by a pharmaceutical composition with the characteristics of the patent claim 1.
The inventive pharmaceutical composition with at least one systemically and/or locally effective, topically applicable active substance, being preferably selected from the group consisting of local anaesthetics, anti-allergic agents, dermatics, active substances for influenzal infections and colds, active substances for the treatment of neuropathies, chemotherapeutics, quinine, thalidomide, analgesics, non-steroid antirheumatics, opiate receptor agonists, opiate receptor antagonists, substances inhibiting the blood coagulation, substances inhibiting platelet aggregation, corticoids, histamine antagonists, anti-diabetics, regulatory peptides and the inhibitors thereof, prostaglandins and/or the esters thereof and/or antivirally effective substances, is not provided as tablet, dragee, suppository, injection or infusion, cream or ointment, as the initially mentioned prior art claims, instead it has such a liquid consistency that it can be sprayed in droplets, whereby after being sprayed the composition forms a preparation within short time, preferably within a time of less than 4 seconds, on the sprayed body surface, particularly on the sprayed skin or mucous membrane, whereby, compared to the original liquid composition, this preparation is formed in such a preparation which has an essentially higher concentration of the active substance and which contains the active substance in a finely divided way.
In order to avoid confusions and for the easy understanding, the form of application which can be sprayed in droplets, meaning thus the form of application being available in the trade, is designated in the present application as inventive pharmaceutical composition, whereas the form of application which is formed from the s
REFERENCES:
patent: 3592891 (1971-07-01), Dawson et al.
patent: 4144319 (1979-03-01), Willer et al.
patent: 4464378 (1984-08-01), Hussain
patent: 5008293 (1991-04-01), Berger
patent: 5192528 (1993-03-01), Radhakrishnan et al.
patent: 5431914 (1995-07-01), Adekunle et al.
Artmann Carl
Regenold Juergen
Roeding Joachim
Mika Pharma Gesellschaft Fuer Die Entwicklung Und Vermarktung
Weddington Kevin E.
LandOfFree
Pharmaceutical composition does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical composition, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical composition will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-699961