Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1987-10-15
1989-10-03
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424468, 424475, 424489, 424499, 424501, A61K 926
Patent
active
048715450
ABSTRACT:
Nifedipine is a well-known calcium antagonist, and salbutamol is a much used bronchodilator. Yet a pharmaceutical combination containing both substances is not known. Prior experience with the administration of nifedipine in combination with beta.sub.2 -sympathomimetica did not make any combinatory effect appear probable. It was further to be feared that any combinatory effect would be accompanied by correspondingly increased side effects. The new pharmaceutical composition is nevertheless intended to provide a combination of nifedipine with a beta.sub.2 -sympathomimeticum usable for systemic application especially in cases of asthmatic diseases. According to the invention, the pharmaceutical combination contains salbutamol besides nifedipine. The combined effect of the active substances is super-additive and synergistic. Nevertheless, no addition of side effects is experienced. The therapeutic effect of the combination corresponds approximately to the maximum achievable improvement.
REFERENCES:
patent: 4317930 (1982-03-01), Hirose et al.
patent: 4337272 (1982-06-01), Bernareggi et al.
patent: 4582840 (1986-04-01), Garthoff et al.
patent: 4652563 (1987-03-01), Slater
patent: 4716041 (1987-12-01), Kjornaes et al.
patent: 4719226 (1988-01-01), Otsuka et al.
patent: 4758433 (1988-07-01), Johnson et al.
Euro-Celtique S.A.
Page Thurman K.
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