Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-05-03
2005-05-03
Travers, Russell (Department: 1617)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S050000, C514S226200, C514S253010, C514S307000, C514S365000
Reexamination Certificate
active
06887879
ABSTRACT:
In accordance with the present invention there is provided a pharmaceutical combination useful for the treatment of viral infections comprising a at least one antiviral active compound of formula (1):and at least one further therapeutic agent chosen from nucleoside analogues; NNRTIs; and protease inhibitors.
REFERENCES:
patent: 4724232 (1988-02-01), Rideout et al.
patent: 5041449 (1991-08-01), Belleau et al.
patent: 5179104 (1993-01-01), Chu et al.
patent: 5270315 (1993-12-01), Belleau et al.
patent: 5276151 (1994-01-01), Liotta
patent: 5366972 (1994-11-01), Hargrave et al.
patent: 5444063 (1995-08-01), Schinazi
patent: 5684010 (1997-11-01), Schinazi
patent: 5767122 (1998-06-01), Chu et al.
patent: 5792773 (1998-08-01), Chu et al.
patent: 5830898 (1998-11-01), Schinazi et al.
patent: 5834474 (1998-11-01), Schinazi
patent: 5925643 (1999-07-01), Chu
patent: 631 786 (1989-10-01), None
patent: WO 9210497 (1992-06-01), None
Gulnik et al, Biochemistry, vol. 34, pp. 9282-9287.*
Chu et al, J. Org. Chem, vol. 56, pp. 6503-6505, 1991.*
Chen, Huachun et al. “Pharmacokinetics of (-)-β-D-2-Aminopurine Dioxolane and (-)-β-D-2-Amino -6-Chloropurine Dioxolane and Their Antiviral Metabolite (-)-β-D-Dioxolane Guanine in Rhesus Monkeys”Antimicrobial Agents and Chemotherapy, 40, 2332-2336 (1996).
Chen, Huachun et al. “Pharmacokinetics of (-)-β-D-Dioxolane Guanine and Prodrug (-)-βD- 2,6-Diaminopurine Dioxolane Following Intravenous Administration to Rats” manuscript submitted toAntimicrobial Agents&Chemo-therapy.
Chen, Huachun et al. “Pharmacokintecs of (-)-β-D-2,6-Diaminopurine Dioxolane and its Metabolite (-)-β-D-Dioxolane Guanine in Rhesus Monkeys” (Draft manuscript).
Good, Steven S et al. “Disposition in the Dog and the Rat of 2,6-Diamino-9-(2-Hydroxyethoxymethyl)Purine(A134U), a Potential Prodrug of Acyclovir”The Journal of Pharmacology and Experimental Therapeutics227, 644-651, USA.
Gu, Z. et al. “Mechanism of Action and In Vitro Activity of 1′,3′-Dioxolanylpurine Nucleoside Analogues against Sensitive and Drug-Resistant Human Immunodeficiency Virus Type 1 Variants,”Antimicrobial Agents and Chemotherapy, 43, 2376-2382 (1999).
Kim, H. O., et al., “Asymmetric Synthesis of 1,3-Dioxolane-Pyrimidine Nucleosides and Their Anti-HIV Activity”,Journal of Medicinal Chemistry, 1992, vol. 35, No. 11, pp. 1987-1992.
Kim, Hea O. et al. “1,3-Dioxolanylpurine Nucleosides (2R,4R) and (2R,4S) with Selective Anti-HIV-1 Activity in Human Lymphocytes”Journal of Medicinal Chemistry36, 30-37.
Kim, Hea O. et al. “L-β-(2S-4S)- and L-α-(2S,4R)-Dioxolanyl Nucleosides as Potential Anti-HIV Agents: Asymmetric Synthesis and Structure-Activity Relationships”Journal of Medicinal Chemistry36, 519-528.
Kim, Hea O. et al. Potent Anti-HIV and Anti-HBV Activities of (-)-L-β-Dioxolane-C and (+)-L-β-Dioxolane-T and Their Asymmetric Syntheses.Tetrahedron Letters, vol. 33, No. 46, pp. 6899-6902, 1992.
Norbeck, Daniel W. et al. “(±)-1-[(2β, 4β)-2-(Hydroxymethyl)-4-dioxolanyl]thymine) A new 2′,3′-Dideoxynucleoside Prototype with In Vitro Activity Against HIV” Tetrahedron Letters, 30, 6263-6266 (1989).
Schinazi, R. F. et al. “Developmenty of (-)-β-D-2,6-Diaminopurine Dioxolane as a Potential Antiviral Agent”,Antiviral Research, vol. 23, Supplement 1 (1994).
Spector, Thomas et al. “Conversion of 2,6-Diamino-9-(2-Hydroxyethoxymethyl) Purine to Acyclovir as Catalyzed by Adenosine Deaminase”Biochemical Pharmacologyvol. 32. No. 17, pp. 2505 2509, 1983 Great Britian.
Triangle Pharmaceuticals, website, “DAPD: A Potential Antiviral Purine Nucleoside Analogue,” site last updated on Feb. 5, 1999.
Gulnik et al., Biochemistry, vol. 34, pp. 9282-9287.
Gu Zhengxian
Rando Robert F.
Millen White Zelano & Branigan P.C.
Shire BioChem Inc.
Travers Russell
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