Pharmaceutical combination

Details Pharmaceutical combination Pharmaceutical combination

2006-09-05

2006-09-05

Krass, Frederick (Department: 1614)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

C514S075000, C514S081000, C514S082000, C514S085000, C514S120000, C514S179000

Reissue Patent

active

RE039264

ABSTRACT:
The invention relates to pharmaceutical compositions for topical administration comprising a topically acceptable antiviral substance and an antiinflammatory glucocorticoid in a pharmaceutically acceptable carrier. The pharmaceutical composition can be used in the prophylactic and curative treatment of herpesvirus infections in mammals including man. The invention also relates to the use of a combination of a topically acceptable antiviral substance and an antiinflammatory glucocorticoid for the manufacture of a medicament for said prophylactic and curative treatment.

REFERENCES:
patent: 3317384 (1967-05-01), Underwood
patent: 4512978 (1985-04-01), Inwood
patent: 4610868 (1986-09-01), Fountain et al.
patent: 4902678 (1990-02-01), Smith
patent: 4942031 (1990-07-01), Levin
patent: 5023090 (1991-06-01), Levin
patent: 5656301 (1997-08-01), Levin
patent: 5856364 (1999-01-01), Martin
patent: 6068860 (2000-05-01), Carlsson et al.
patent: 6514980 (2003-02-01), Boyd
patent: 2004/0185433 (2004-09-01), Boyd
patent: 0636255 (1992-05-01), None
patent: 636255 (1993-04-01), None
patent: 0350287 (1990-01-01), None
patent: 0594223 (1994-04-01), None
patent: 9219244 (1992-11-01), None
patent: 9503805 (1995-02-01), None
patent: 9527501 (1995-10-01), None
Alenius, S., et al; Therapeutic Effects of Foscarnet Sodium and Acyclovir on Cutaneous Infections due to Herpes Simplex Virus Type 1 in Guinea Pigs, J. Inf. Dis. 1982; 145:569-73.
The Human Herpesviruses, ed. Roizman et al. 1993, Whitely, Richard et al; The epidemiology and Clinical Manifestations of Herpes Simplex Virus Infections.
Kristofferson, A. et al.; Limited Efficacy of Inhibitors of Herpes Simplex Virus DNA Synthesis in Murine Models of Recrudescent Disease, J. Gen. Virol. (1988), 69, 1157-1166.
Schinazi, R.F. et al; Studies in Vitro and In Vivo of Combinations of Antivirals and Antiinflammatory Agents in Relation to the Treatment of Herpes Simplex Viruses, Current Chemotherapy and Immunotherapy, 12th Int. Congress, Florence, Jul. 1981.
From Chemical Abstracts, vol. 112, nr. CA:125021: Loftsson, T.; Effect of choline esters and oleic acid on the penetration of acyclovir, estradiol, hydrocortisone, nitroglycerin, retinoic acid and trifluorothymidine across hairless mouse skin in vitro, Acta Pharm. Nor. (1989), 1(5), 279-86.
From Chemical Abstracts, vol. 112, nr 4 (dissertation): Choi, Hoo Kyun: Enhanced transdermal delivery of propanolol, hydrocortisone, acyclovir and peptide-type drugs (1989).
Power, W J et al, Acyclovir ointment plus topical betamethasone or placebo in first episode disciform keratitis, British Journal of Opthalmology 1992; 76:711-713.
McGill, J. Herpes zoster ocular infection, Scand. J. Infect. Dis. Suppl. 46: 85-88, 1985.
ABPI Compendium of Data Sheets and Summaries of Product Characteristics, 1996-97, Datapharm Publications Ltd., pp. 390 and 1271.
Bekow, et al., the Merck Manual of Diagnosis and Therapy, 14th Edition, pp. 2023-2025 (1982).
Chemical Abstract No. 97: 156002r from Schinazi et al., Curr. Chemother. Immunother. 2, 1085-1087 (1982).
Merck Index 10th Ed #140, #4135, #1435, 1984.
Notter et al., 89 CA:157769t, 1978.
Chemical Abstracts 103:572328, “The antiinflammatory effect of budesonide”, Hiroi et al, from STN File CAPLUS database (first publicly available Nov. 30, 1985).
F.Y. Aoki et al., “Topical glucorticoid alone or combined with 10% acyclovir . . . ,” XP-001117608. Abstract and Clarified Text. (1988).
W.J. Power et al., “Acyclovir ointment plus topical betamethasone or placebo . . . ,” British Journal of Ophthalmology, 1992, vol. 76, pp. 711-713.
J. McGill, “Herpes zoster ocular infection,” Scand J. Infect. Dis., Suppl., 1958,47, pp. 85-88.
Harmenburg, J. et al., “ME-609: a treatment for recurrent herpes . . . ,” International Medical Press, 2003, pp. 205-215.
Harmenburg, J. et al., “ME-609: a treatment for recurrent herpes . . . ,” Manuscript, pp. 1-30. (2003).
Evans, T.G. et al, “Double-blind randomized, placebo-controlled . . . ,” Antimicrobial Agents and Chemotherapy, Jun. 2002, pp. 1870-1874.

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