Pharmaceutical capsules from improved thermogelling methyl cellu

Details Pharmaceutical capsules from improved thermogelling methyl cellu Pharmaceutical capsules from improved thermogelling methyl cellu

1975-10-01

1977-01-04

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

106170, 106197R, 264 25, 264301, 264DIG37, 424 35, B29C 1300, C08B 1108, C08B 11193

Patent

active

040012115

ABSTRACT:
Improved thermogelling methyl cellulose ether compositions for use in preparing pharmaceutical capsules by the pin dip coating process are prepared by blending the properties of water soluble methyl and C.sub.2 -C.sub.3 hydroxyalkyl cellulose ethers to achieve an essentially Newtonian dip coating solution and a rapid high thermal gel yield strength. These properties require a cellulose ether with a relatively narrow molecular weight distribution. Blends of low viscosity methyl cellulose and hydroxypropylmethyl cellulose provide particularly suitable dip solution properties, gel yield strength, and capsule dissolution rates.

REFERENCES:
patent: 2526683 (1950-10-01), Murphy
patent: 3014808 (1961-12-01), Nyberg
patent: 3453261 (1969-07-01), Scherff
patent: 3493407 (1970-02-01), Greminger et al.
patent: 3617588 (1971-11-01), Langman
patent: 3712886 (1973-01-01), Koyanagi et al.
patent: 3852421 (1974-12-01), Koyanagi et al.
patent: 3870702 (1975-03-01), Koyanagi et al.

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