Pharmaceutical article of manufacture comprising a bisulfite sta

Details Pharmaceutical article of manufacture comprising a bisulfite sta Pharmaceutical article of manufacture comprising a bisulfite sta

1985-03-28

1987-04-14

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514973, A61K 31615

Patent

active

046579001

ABSTRACT:
An aqueous suspension of pure 5-aminosalicylic acid adapted for rectal administration is rendered storage stable against color formation by storing the suspension in a single dose polyethylene bottle adapted for rectal administration of the suspension, in a substantially oxygen-free atmosphere and in the presence dissolved therein of up to about 0.25% of bisulfite and protecting the suspension from exposure to atmospheric oxygen during storage by sealing the plastic bottle, in a substantially oxygen-free atmosphere, in a plastic pouch having a low oxygen transmission rate.

REFERENCES:
patent: 2939818 (1960-06-01), Berger
patent: 3230143 (1966-01-01), Marcus
patent: 3777019 (1973-12-01), Levin
patent: 4071620 (1978-01-01), Sklar
patent: 4406888 (1983-09-01), Aquiar et al.
patent: 4440763 (1984-04-01), Lover
Husa's--"Pharmaceutical Dispensing", Martin, Sixth ed., Mack Pub. Co., Easton, Penna. (1966).

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