Pharmaceutical applications for methanediphosphonate derivative

Details Pharmaceutical applications for methanediphosphonate derivative Pharmaceutical applications for methanediphosphonate derivative

1996-03-15

1997-11-04

Ambrose, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Silicon containing doai

514107, 556405, 558158, 558161, 562 13, A61K 31695, A61K 3166

Patent

active

056839928

ABSTRACT:
The present invention relates to a methanediphosphonate derivative, its manufacturing process, and pharmaceutical applications, that is represented with the following formula: ##STR1## wherein, D is either sulfur, oxygen, NH, alkyl-substituted N, CH.sub.2, or SCH.sub.2, X represents an alkyl group, alkyl group having a hetero atom as a substitution group, an aryl group or an acyl group, m represents an integer of 1 to 5, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 independently represent hydrogen, alkyl groups having 1 to carbon atoms or pharmaceutically allowable cations. .function.The compounds of the present invention have excellent IL-1 inhibitory action, antioxidation action and bone resorption inhibitory action, and are useful as antiinflammatory agents, antirheumatic agents, bone metabolic disease drugs, autoimmune disease drugs, or osteoporosis drugs.

REFERENCES:
patent: 3609075 (1971-09-01), Barbera
patent: 4473560 (1984-09-01), Biere et al.
patent: 4746654 (1988-05-01), Breliere et al.
patent: 4876247 (1989-10-01), Barbier et al.
patent: 4876248 (1989-10-01), Breliere et al.
patent: 4902679 (1990-02-01), Benedict et al.
patent: 5043330 (1991-08-01), Nguyen et al.
patent: 5128331 (1992-07-01), Nguyen et al.
patent: 5153183 (1992-10-01), Kawabe et al.
patent: 5157027 (1992-10-01), Biller et al.
patent: 5256808 (1993-10-01), Alexandratos

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