Pharmaceutical amides, and preparation, formulations and use of

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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260456A, 260465E, 2605025D, 260940, 260941, 424210, 424211, 560 12, 560 13, 560 16, 560 22, 560 39, C07F 938, C07C 69612, A61K 3166, A61K 31215

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044232420

ABSTRACT:
Compounds of the general formula ##STR1## wherein Ph is a phenyl group which is optionally substituted by one or more substituents selected from halo (i.e. fluoro, chloro, bromo or iodo), C.sub.1-4 alkyl, amino, C.sub.1-4 alkylamino, di-C.sub.1-4 alkylamino, nitro, sulphonyl, aminosulphonyl, trihalomethyl, carboxy, C.sub.1-4 alkoxycarbonyl, amido, C.sub.1-4 alkylamido C.sub.1-4 alkoxy, C.sub.2-4 alkenyl, cyano, aminomethyl or methylsulphonyl; R.sup.a and R.sup.b, which may be the same or different, each represents a hydrogen or alkali metal (e.g. sodium or lithium) atom or a C.sub.1-4 (e.g. ethyl) group; m is 0 or 1; Y is a group of formula:

REFERENCES:
patent: 4105689 (1978-08-01), Auer et al.
patent: 4154759 (1979-05-01), Parsons et al.
patent: 4168267 (1979-09-01), Petrillo
patent: 4226610 (1980-10-01), Takematsu et al.
patent: 4272528 (1981-06-01), Von Esch et al.
patent: 4396772 (1983-08-01), Petrillo, Jr.
patent: 4399287 (1983-08-01), Baillie et al.

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