Pharmaceutical agents for the treatment of sickle cell disease

Details Pharmaceutical agents for the treatment of sickle cell disease Pharmaceutical agents for the treatment of sickle cell disease

1980-06-06

1983-06-28

Rosen, Sam

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

4242485, 42424852, 42424853, 42424854, 42424855, 424263, 424273R, 424274, 424275, 424309, 424320, 424324, A61K 3700

Patent

active

043905269

ABSTRACT:
The present invention relates to novel compounds selected from R.sub.1 --COO(CH.sub.2).sub.n --R.sub.2 and ##STR1## wherein R.sub.1 is selected from heterocyclic aromatic and hydrophobic naturally occuring and modified amino acids in the D- and in the L-form, and from peptides, wherein n is an integer of from 1 to 5 and R.sub.2 is selected from unsubstituted and substituted phenyl rings, and from heterocyclic rings, as well as to pharmaceutical compositions for preventing sickling of erythrocytes during sickle cell crisis and for desickling of sickle cells of patients afflicted by sickle cell disease, the active ingredient of which is a compound as defined above.

REFERENCES:
patent: 3466321 (1969-09-01), Morrew
patent: 3714228 (1973-01-01), Massie
patent: 3983138 (1976-09-01), Saari
patent: 4243819 (1981-01-01), Henrick et al.
Shirahawa et al.-Chem. Abst., vol. 93, (1980), p. 125443y.
Stuetz et al.-Chem. Abst., vol. 82, (1975), p. 156,375e.
Maclaren-Chem. Abst., vol. 77, (1972), p. 34902a.

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