Pharmaceutical agents for the treatment of disorders caused by h

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514925, 514926, 514927, 514329, A61K 3144

Patent

active

057505357

ABSTRACT:
The present invention relates to a method treating or preventing disorders caused by a spiral urease-positive gram-negative bacterium such as Helicobacter pylori in mammals, including humans, using compounds that are substance P receptor antagonists and, specifically, using certain quinuclidine derivatives, piperidine derivatives, pyrrolidine derivatives, azanorbornane derivatives, ethylene diamine derivatives and related compounds.

REFERENCES:
patent: 5232929 (1993-08-01), Desai et al.
patent: 5294744 (1994-03-01), Godek et al.
Parnet et al. "Substance P: A possible link between teh infectious and stress theories of ulcerogenesis. Preliminary results" Abstract in Acta Gastro-Enterologica Belgica. V. 56, Supplement. p. 64. Sep. 1993.
Blaser. "Hypotheses on the Pathogenesis and Natural History of Helicobacter pylori-Induced Inflammation" Gastroenterology. 102:720-727. 1992.
Blaser, M. J., Clinical Infectious Disease, 15, 386-93 (1992).
Hussel et al., Abstract: Acta Gastroenterologica Belgica, 56, Suppl. 52 (1993).
Parnet et al., Abstract: Acta Gastroenterologica Belgica, 56, Suppl. 64 (1993).

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