Pharmaceutical agents containing acyclovir, fusaric acid and...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S262100, C514S252110

Reexamination Certificate

active

06939884

ABSTRACT:
Compositions are provided, which comprise at least one nucleoside analogue inhibitor, pharmaceutically acceptable salts, solvates, or prodrugs thereof and fusaric acid, derivatives, or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprising the above compositions are also provided that optionally further include another therapeutically effective compound, such as a carrier. Systemic and topical preparations comprising the above compositions are also provided as well as methods of treating viral diseases by the administration of the above antiviral agents to a patient.

REFERENCES:
patent: 5767135 (1998-06-01), Fernandez-Pol
patent: 6127393 (2000-10-01), Fernandez-Pol
Physicians Desk Reference, Ed. 51, 1997, pp. 1187-1194.
Transfusion Science, vol. 23, n 3, Dec. 2000 (249-250); “Combining iron chelators with the nucleoside analog didanosine in anti-HIV Therapy”; by Georgiou, Niki A. et al.
Journal of Chemotherapy, vol. 5, -n. 1 (3-9) 1993: Mode of Action of Zn-Complexes on Herpes Simplex Virus Type 1 Infection in Vitro; by T.L. Varadinova, P.R. Bonchev; C.K. Nachev; S.A. Shishkov; D. Strachilov; Z. Paskalev; A. Toutekova and M. Panteva.
Journal of Pharmaceutical Sciences, vol. 77 n 4, Apr. 1988 (285-298) : Glycolamide Esters as Biolabile Prodrugs of Carboxylic Acid Agents: Synthesis, Stability, Bioconversion, and Physicochemical Properties; by Neils Mork Nielsen and Hans Bungaard.
Handbook of Animal Models of Infection 1988, Aug.; 9 (5) 911-918; Animal Models of Herpes Skin Infection: Guinea-pig by Spruance SL, McKeough MB.
Journal of Pharmaceutical Sciences, an.1977; vol. 66 (1): 1-19. Pharmaceutical Salts; Berge SM, Bighley LD et al.
Anticancer Research 21:931-958 (2001) Essential Viral and Cellular Zinc and Iron Containing Metalloproteins as Targets for Novel Antiviral and Anticancer Agents: Implications for Prevention and Therapy of Viral Diseases and Cancer; J. Alberto Fernandez-Pol, Paul D. Hamlton and Dennis J. Klos.

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