Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-09-03
1994-10-04
Morris, Patricia L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548469, C07D20908, A61K 31405
Patent
active
053526945
ABSTRACT:
A physical form of (R)-3-methoxy-4-[1-methyl-5-(2-methyl-4,4,4-trifluorobutylcarbamoyl)indol -3-ylmethyl]-N-(2-methylphenylsulphonyl)benzamide substantially free of other physical forms, which form is crystalline and has an X-ray powder diffraction pattern with specific peaks at 2.theta.=14.0, 19.4, 22.0, 22.4 and 24.7.degree. , processes for preparing the form and pharmaceutical compositions containing it. The compound is a leukotriene antagonist useful in the treatment of diseases such as asthma.
REFERENCES:
patent: 4918094 (1990-04-01), Bernstein et al.
Gassen, K.; Kirmse, W., "Zun Einfluss von Trifluormethylgruppen auf die Reaktionen aliphatischer Diazonium-Ionen and Carbokationen", Chem. Ber., (1986), 119, 2233-2248.
Haley Jacqueline
Imperial Chemical Industries plc
Jackson Thomas E.
Morris Patricia L.
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