Pharmaceutical aerosol compositions comprising putrescine prosta

Details Pharmaceutical aerosol compositions comprising putrescine prosta Pharmaceutical aerosol compositions comprising putrescine prosta

1975-10-01

1977-03-29

Rosen, Sam

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424305, 424316, 424317, A61K 900, A61K 31215, A61K 31205

Patent

active

040149897

ABSTRACT:
Novel compounds of the formulae: ##STR1## wherein R.sub.2 and R.sub.6 are hydrogen when Z.sub.2 is a single bond and when Z.sub.2 is a double bond R.sub.2 and R.sub.6 are absent; R.sub.3 is a keto, ##STR2## R.sub.7 is OH or OR.sub.9 ; R.sub.8 is H or OH; R.sub.9 is acyl or alkoxyalkyl; R.sub.10 is H or ##STR3## Z.sub.1 is --CH.sub.2 CH.sub.2 -- or cis --CH=CH--; Z.sub.2 is a single bond or a double bond; Z.sub.3 is a single bond or a double bond when R.sub.4 and R.sub.5 are hydrogen; Z.sub.4 is --CH.sub.2 CH.sub.2 -- or trans --CH=CH--; Z.sub.5 is --CH.sub.2 CH.sub.2 -- or cis --CH=CH--; n is 2 to 5, m is 1 to 3, and x is 1 to 2. The compounds are useful for regulating blood pressure, for stimulating smooth muscles, for inhibiting gastric secretion and inhibiting platelet aggregation and they possess improved biological stability and enhanced membrane permeability to serve as an in vivo reservoir of the prostaglandin to ensure the biological availability of the prostaglandin.

REFERENCES:
patent: 2165470 (1939-03-01), Fisk
patent: 3271248 (1966-09-01), Renault et al.
patent: 3764620 (1973-10-01), Zaffaroni

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