Pharmaceutical administration systems containing a mixture of im

Details Pharmaceutical administration systems containing a mixture of im Pharmaceutical administration systems containing a mixture of im

1985-07-09

1988-09-27

Hazel, Blonde L.

Drug, bio-affecting and body treating compositions

Lymphokine

Interferon

435 68, A61K 4502, C12P 2100

Patent

active

047740850

ABSTRACT:
The present invention relates to pharmaceutical administration systems containing phosphatidylserine and phosphatidylcholine or phosphatidylethanolamine derivatives in the form of liposomes which encapsulate water soluble muramyldipeptide derivatives in combination with gamma-interferon. The liposomes are prepared by conventional dispersion methods. The pharmaceutical administration systems when applied in the form of liposomes are especially useful in the cancer chemotherapy for combating metastatic tumor cells.

REFERENCES:
patent: 4522811 (1985-06-01), Eppstein et al.
Saiki et al., Cancer Research, vol. 45, pp. 6188-6193, 1985.
Chemical Abstracts, vol. 104, Abstract No. 18480g, 1986.
Chemical Abstracts, vol. 103, Abstract No. 52561y, 1985.
Journal of Immunology, 131, No. 6. Dec. 1983, pp. 2821-2825.
Journal of Immunology, 125, No. 6. Dec. 1980, pp. 2454-2460.
Cancer Research, 39, Mar. 1979, pp. 881-892.
Journal of Clinical Investigation, 72, Jul. 1983, pp. 304-315.

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