Phalloidin derivatives and methods for their synthesis

Details Phalloidin derivatives and methods for their synthesis Phalloidin derivatives and methods for their synthesis

2011-06-21

2011-06-21

Tsang, Cecilia (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Synthesis of peptides

Reexamination Certificate

active

07964702

ABSTRACT:
The invention provides a cyclomonomer having actin-binding activity. The cyclomonomer is of utility for the study of the molecular biology of actin polymerization. The cyclomonomer is also useful for the study of and treatment of the toxic effects ofAmanitasp. poisoning.

REFERENCES:
Anderson et al (J Org Chem ‘A solid-phase approach to the phallotoxins: total synthesis of [Ala7]-phalloidin’ (2005) 70, pp. 4578-4584).
Zanotti et al (Chem Eur J ‘Solid state and solution conformation of [Ala7]-phalloidin: a synthetic phallotoxin analogue’ (2001) 7 No. 7 pp. 1479-1485).
Anonymous,Peptide Synthesis, Wikipedia online free encyclopedia, http://en.wikipedia.org/wiki/Peptide—synthesis, dated Jan. 5, 2011; downloaded and printed Jan. 6, 2011.
Anonymous,Tetrakis(triphenylphosphine)palladium, Chemical Book webpage, http://www.chemical book.com/Chemical/ProductProperty—EN—CB6163934.htm downloaded and printed Oct. 14, 2010.
Anonymous,Dichloromethane, Wikipedia online free encyclopedia, http://en.wikipedia.org/wiki/Dichloromethane, dated Jan. 6, 2011; downloaded and printed Jan. 6, 2011.
Anonymous,Non-nucleophilic base, Wikipedia online free encyclopedia, http://en.wikipedia.org/wiki/Non-nucleophilic—base, dated Apr. 7, 2010; downloaded and printed Oct. 14, 2010.

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