Phage display technologies

Details Phage display technologies Phage display technologies

2006-07-06

2010-10-12

Lundgren, Jeffrey S (Department: 1639)

Combinatorial chemistry technology: method, library, apparatus

Library, per se

Library contained in or displayed by a micro-organism or...

C435S320100, C506S026000

Reexamination Certificate

active

07811973

ABSTRACT:
The present invention provides novel technologies for producing and screening fusion proteins on the surface of filamentous phage. In particular, a single vector can be used for generating cell and phage libraries containing a given series of protein sequences fused to either one or other of two phage coat proteins. This approach simplifies and improves the efficiency of the subsequent phage display-based selection of protein-binding molecules having therapeutic or diagnostic utility, such as antibodies, peptides, or epitope-binding regions.

REFERENCES:
patent: 2005/0112550 (2005-05-01), Gershoni et al.
Wang (Dec. 18, 1997 Molecular Immunology vol. 34 p. 609).
Solomon (May 21, 2004 Protein Expression and Purification vol. 36 p. 226).
Ryu (Mar. 2004 Plant Molecular Biology vol. 54 p. 489).
Liang (Nov. 16, 2001 The Journal of Biological Chemistry vol. 277 p. 3593).
Databadse WPI week 2000367, Derwent Publications Ltd., London, GB, AN 2003-712730, XP002413848 & WO 03/072773 A1 (American Biosciences KK), Sep. 4, 2003.
Den W. et al, “A bidirectional phage display vector for the selection and mass transfer of polyclonal antibody libraries” Journal of Immunological Methods, Elsevier Science Publishers B.V., Amsterdam, NL, vol. 222, No. 1-2, Jan. 1999, pp. 45-57, XP004152426.

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