Phage-display peptides as novel antimicrobial agents against...

Details Phage-display peptides as novel antimicrobial agents against... Phage-display peptides as novel antimicrobial agents against...

2007-07-03

2007-07-03

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C422S028000, C427S002100, C427S002240, C427S002300, C436S501000, C530S326000

Reexamination Certificate

active

10655562

ABSTRACT:
Whole cell phage-display techniques were used to identify several peptides that bound preferentially to a non-typeable strain ofHaemophilus influenzae. These peptides were able to inhibit growth of bothH. influenzaeandStaphylococcal aureus. Thus, methods for treating bacterial infections, alone or in combination with traditional antibiotics, are envisioned.

REFERENCES:
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patent: 6180604 (2001-01-01), Fraser et al.
patent: 2003/0143671 (2003-07-01), Adler et al.
Boyle-Vavra et al., “Reversion of the glycopeptide resistance phenotype inStaphylococcus aureusclinical isolates,”Antimicrob. Agents Chemother., 44(2):272-277, 2000.

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