Surgery – Controlled release therapeutic device or system – Osmotic or diffusion pumped device or system
Patent
1994-10-19
1997-03-11
Green, Randall L.
Surgery
Controlled release therapeutic device or system
Osmotic or diffusion pumped device or system
424468, 424453, 424472, A61K 922
Patent
active
056095902
ABSTRACT:
An osmotic bursting device for dispensing a beneficial agent to an aqueous environment. The device comprises a beneficial agent and osmagent surrounded at least in part by a semipermeable membrane. Alternatively the beneficial agent may also function as the osmagent. The semipermeable membrane is permeable to water and substantially impermeable to the beneficial agent and osmagent. A trigger means is attached to the semipermeable membrane (e.g., joins two capsule halves). The trigger means is activated by a pH of from 3 to 9 and triggers the eventual, but sudden, delivery of the beneficial agent. These devices enable the pH-triggered release of the beneficial agent core as a bolus by osmotic bursting.
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Herbig Scott M.
Smith Kelly L.
Alexander V.
Benson Gregg C.
Green Randall L.
Olson A. Dean
Pfizer Inc.
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