pH stabilized fluorescing ophthalmic composition containing fluo

Details pH stabilized fluorescing ophthalmic composition containing fluo pH stabilized fluorescing ophthalmic composition containing fluo

1979-08-31

1985-05-21

Rosen, Sam

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 71, 436172, G01N 3100, G01N 3348, A01N 4390

Patent

active

045185794

ABSTRACT:
An ophthalmic composition for use in the human eye comprising an aqueous solution of fluorexon whose pH has been adjusted to between pH 5.4 and 6.2 to deliver maximum fluorescence and additionally containing sufficient buffer to maintain that pH even after instillation into the eye.

REFERENCES:
patent: 3306820 (1967-02-01), Krezanoski
patent: 3374144 (1968-03-01), Stolar
Refojo et al., J. Amer. Optometric Asso., vol. 43, No. 3, Mar. 1972, pp. 321-326.
Refojo et al., Arch Ophthal., vol. 87, Mar. 1972, pp. 275-277.
Norm, Acta Ophthalmologica, vol. 51, 1973, pp. 670-678.
Hoelzl Wallach, Anal. Chem., vol. 31, 1959, pp. 456-460.

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