pH sensitive, reversible gelling, copolymeric erodible drug deli

Details pH sensitive, reversible gelling, copolymeric erodible drug deli pH sensitive, reversible gelling, copolymeric erodible drug deli

1992-02-25

1994-03-08

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424428, 424486, 424 7833, 514912, 514944, 5147726, 523122, A61K 908, A61K 4732

Patent

active

052925170

ABSTRACT:
pH sensitive, reversible gelling erodible drug delivery compositions and methods for their production are disclosed. The compositions are liquid solutions of poly(methylvinylether/maleic acid) having pharmaceutical compounds incorporated therein. The poly(methylvinylether/maleic acid) solutions increase in viscosity with increases in pH. Thus, when the compositions are formulated at a pH lower than physiological pH's, and then delivered to a target physiological site, the liquid solution becomes viscous and adheres to the tissue for a length sufficient to provide prolonged bioavailability of the pharmaceutical compound.

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