Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Aftertreated solid synthetic organic polymer
Reexamination Certificate
2004-05-14
2010-02-09
Woodward, M P (Department: 1615)
Drug, bio-affecting and body treating compositions
Designated organic nonactive ingredient containing other...
Aftertreated solid synthetic organic polymer
C424S400000, C514S772000
Reexamination Certificate
active
07659314
ABSTRACT:
Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of treating a warm-blooded animal with such a drug are disclosed.
REFERENCES:
patent: 6410057 (2002-06-01), Kweon-Choi et al.
Valero et al. Phase II study of liposome-encapsulated doxorubicin, cyclophosphamide, and fluolouracil as first-line therapy in paients with metastatic breast cancer. in Journal of Clinical Oncology 1999 17:1425-1434.
Wang et al. Folate-mediated targeting of antineoplastic drugs, imaging agnets, and nucleic acid to cancer cells. Journal of Controlled Release 1998 53:39-48.
Kwon et al. Polymeric micells as new drug cariers. Advanced Drug Delivery Reviews 1996 21:107-116.
Taillefer et al. Preparation and characterization of pH-responsive polymeric micelles for the delivery of photosensitizing anticancer drugs. Journal of Pharmaceutical Sciences 2000 89:52-62.
Choi et al Novel macromollecular self-organization of poly(ethylene glycol)-block-poly(L-histidine):pH-induced formation of core-shell nanoparticles in aqueous media. Bulletin of the Korean Chemical Society 2001 22:261-262.
Muggia et al. Phase II study of liposomal doxorubicin in refractory ovarian cancer:antitumor activity and toxicity modification by liposomal encapsulation. Journal of Clinical Oncology 1997 15:987-993.
Kitano et al. Macromolecules 1991 24:42-46.
Leroux et al. Journal of Controlled Release 2001 72:71-84.
J.M. Benns et al. pH-Sensitive Cationic Polymer Gene Delivery Vehicle:N-Ac-poly(L-histidine)-graft-poly(L-lysine) Comb Shaped Polymer, 11 Bioconjugate Chem. 637-645 (2000).
J.N. Cha et al. Biomimetic synthesis of ordered silica structures mediated by block copolypeptides, 403 Nature 289-292 (2000).
M.P. McCurdie et al. Solid-State Complexes of Poly(L-Histidine) with Metal Chlorides from the First Row of thed-Block, 37 J. Polym. Science: Part B: Polymer Physics. 301-310 (1999).
P. Midoux et al. Efficient Gene Transfer by Histidylated Polylysine/pDNA Complexes, 10 Bioconjugate Chem. 406-411 (1999).
K. Na et al. Self-Assembled Hydrogel Nanoparticles Responsive to Tumor Extracellular pH from Pullulan Derivative/Sulfonamide Conjugate: Characterization, Aggregation, and Adriamycin Release in Vitro, 19 Pharmaceutical Research 681-688 (2002).
D. Putnam et al. Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini, 98 Proc. Nat'l Acad. Sci. 1200-1205 (2001).
C.Y. Wang et al. Polyhistidine Mediates an Acid-Dependent Fusion of Negatively Charged Liposomes, 23 Biochemistry 4409-4416 (1984).
Eun Seong Lee, Kun Na, You Han Bae, Doxorubicin loaded pH-sensitive micelles for reversal of resistant MCF-7 tumor, Journal of Controlled Release, 103 (2005) 405-418.
Eun Seong Lee, Hyun Joon Shin, Kun Na, You Han Bae, Poly (L-histidine)-PEG block copolymer micelles and pH-induced destabilization, Journal of Controlled Release, 90 (2003) 363-374.
Eun Seong Lee, Kun Na, You Han Bae, Polymeric micelle for tumor pH and folate-mediated targeting, Journal of Controlled Release, 91 (2003) 103-113.
Bae You Han
Lee Eun Seong
Na Kun
Clayton Howarth & Cannon, P.C.
Helm Caralynne E
University of Utah Research Foundation
Woodward M P
LandOfFree
PH-sensitive polymeric micelles for drug delivery does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with PH-sensitive polymeric micelles for drug delivery, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and PH-sensitive polymeric micelles for drug delivery will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4168169