pH-sensitive polymeric micelles for drug delivery

Details pH-sensitive polymeric micelles for drug delivery pH-sensitive polymeric micelles for drug delivery

2007-06-12

2007-06-12

Levy, Neil (Department: 1615)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C424S078220, C424S078230, C424S450000, C424S484000, C424S486000, C523S122000

Reexamination Certificate

active

10640739

ABSTRACT:
Mixed micelles containing poly(L-histidine)-poly(ethylene glycol) block copolymer and poly(L-lactic acid)-poly(ethylene glycol) block copolymer are a pH-sensitive drug carrier that release the drug in an acidic microenvironment, but not in the blood. Since the microenvironment of solid tumors is acidic, these mixed micelles are useful for treating cancer, including those cancers exhibiting multidrug resistance. Targeting ligands, such as folate, can also be attached to the mixed micelles for enhancing drug delivery into cells. Methods of making poly(L-histidine), synthetic intermediates, and block copolymers are also described.

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