PH-sensitive polymeric conjugates of an anthracycline...

Details PH-sensitive polymeric conjugates of an anthracycline... PH-sensitive polymeric conjugates of an anthracycline...

2011-04-05

2011-04-05

Hartley, Michael G (Department: 1618)

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

Reexamination Certificate

active

07919076

ABSTRACT:
Conjugates consisting of a polymeric carrier constituted by 30 to 3,000 monomer units linked to form a polymeric chain, composed of a) 60 to 99% of N-(2-hydroxypropyl)methacrylamide units, b) 1 to 25% of units of methacryloylated hydrazones of α-amino acids, ε-amino acids, aromatic amino acids or oligopeptides terminated with a molecule of an anthracycline cancerostatic, c) 0.5 to 15% of units of methacryloylated α-amino acids, ε-amino acids, aromatic amino acids or oligopeptides or their sodium salts.

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