pH-sensitive methacrylic copolymers and the production thereof

Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Polymers from only ethylenic monomers or processes of...

Reexamination Certificate

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C526S217000, C526S219600, C526S234000, C526S264000, C526S288000, C526S291000, C526S303100, C526S304000, C526S307300, C526S317100, C526S328500, C526S347100

Reexamination Certificate

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11284502

ABSTRACT:
The present invention provides novel multi-functional methacrylic copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility under acidic conditions. The copolymers are constructed from tertiary amine methacrylates and poly(ethylene glycol) containing methacrylates. The copolymers are useful as gene vectors, pharmaceutical carriers, and in protein separation applications.

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patent: 2004/0127391 (2004-07-01), Claesson et al.
Anderson et al. Synthesis and characterization of water-soluble block copolymers for pH-sensitive delivery, 2001, Materials Research Society Symposium Proceedings, 662 (Biomaterials for Drug Delivery and Tissue Engineering), NN1.8-NN1.8/6.
Deshpande, et al., Macromolecules 32(6), 2088-2090, 1999.
Hariharan, et al., Polymer, 37(1), 149-161, 1996.

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