pH-sensitive methacrylic copolymer gels and the production...

Details pH-sensitive methacrylic copolymer gels and the production... pH-sensitive methacrylic copolymer gels and the production...

2007-05-15

2007-05-15

Pezzuto, Helen L. (Department: 1713)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Polymers from only ethylenic monomers or processes of...

C526S277000, C526S279000, C526S310000, C526S317100, C526S328500, C526S332000

Reexamination Certificate

active

10366864

ABSTRACT:
The present invention provides novel gel forming methacrylic blocking copolymers that exhibit cationic pH-sensitive behavior as well as good water solubility. The copolymers are constructed by polymerization of a tertiary amine methacrylate with either a (poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) polymer, such as the commercially available Pluronic® polymers, or a poly(ethylene glycol)methyl ether polymer. The polymers may be used for drug and gene delivery, protein separation, as structural supplements, and more.

REFERENCES:
patent: WO 02/100439 (2002-12-01), None
Lee et al. Macromolecules, 35(22), 8540-8551, 2002.
Deshpande et al. J. Controlled Release, 81(1-2), 185-199, 2002.
Even et al. Polymeric Materials Science and Engineering, 84, 955-956, 2001.
Varnvakaki et al. Macromolecules, 32(6), 2088-2090, 1999.
Anderson et al. Mat. Res. Soc. Symp. Proc., 662, NNi.8/1-NN1.8/6, 2001.

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