Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1994-12-15
1998-07-28
Rories, Charles C. P.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435 6, 435 691, 4351721, 4351723, 424 9321, 424450, 4241311, 4241521, 514 44, C12N 1563, C12N 1585, C12N 1588
Patent
active
057862141
ABSTRACT:
This invention relates to pH-sensitive immunoliposomes with a conjugated antibody sensitive to cells of the mammalian CNS, a method for introducing genetic material into the cells of the mammalian CNS in vitro through these liposomes, and a method of introducing genetic material into the cells of the mammalian CNS through direct injection of the liposomes into the CNS.
REFERENCES:
patent: 4089801 (1978-05-01), Schneider
patent: 4675310 (1987-06-01), Chapman et al.
patent: 4693994 (1987-09-01), McCutchan et al.
patent: 4707357 (1987-11-01), Dame et al.
patent: 4708933 (1987-11-01), Huang et al.
patent: 4789633 (1988-12-01), Huang et al.
patent: 4863717 (1989-09-01), Keana
patent: 4906476 (1990-03-01), Radhakrishman
patent: 4925661 (1990-05-01), Huang
patent: 4957735 (1990-09-01), Huang
patent: 4959353 (1990-09-01), Brown et al.
patent: 5049388 (1991-09-01), Knight et al.
patent: 5049389 (1991-09-01), Radhakrishman
patent: 5059421 (1991-10-01), Loughrey et al.
patent: 5092841 (1992-03-01), Spears
patent: 5100662 (1992-03-01), Bolcsak et al.
patent: 5135737 (1992-08-01), Keana
patent: 5137720 (1992-08-01), Gangemi et al.
patent: 5198224 (1993-03-01), Ono et al.
patent: 5199951 (1993-04-01), Spears
patent: 5283185 (1994-02-01), Epand et al.
patent: 5428132 (1995-06-01), Hirsch et al.
ph-Sensitive and Target Sensitive Immunoliposomes for Drug Targeting. Eric C. Holmberg & Leaf Huang, Liposomes in the Therapy of Infectious Diseases and Cancer. 1989. pp. 25-34.
A Rapid Alkaline Extraction Procedure for Screening Recombinant Plasmid DNA. H.C. Birnboim and J. Doly. Nucleic Aids Research, vol. 7, No. 6., 1979. pp. 1513-1523.
A Monoclonal Antibody Detaches Embryonic Skeletal Muscle from Extracellular Matrices. N. T. Neff, C. Lowrey et al. Journal of Cell Biology, vol. 95. Nov. 1992. pp. 654-666.
Antibody Directed Lipsomes as Drug Delivery Vehicles. Stephen Wright & Leaf Huang. Advanced Drug Delivery, Rev. 3, 1989 pp. 343-389.
Monoclonal Antibody Targetin of Liposomes to Mouse Lung in Vivo. Brenda J. Hughes, Stephen Kennel et al. Cancer Research 49. Nov. 15, 1989, pp. 6214-6220.
Structural and Functional Comparisons of pH-sensitive liposomes composed of phosphatidylethanolamine and Three Different Diacylsuccinylglycerols. David Collins, David C. Litzinger, Leaf Huang. Bioschimica et Biophysica Acta, 1990. pp. 234-242.
Characterization of in Vivo Immunoliposome Targeting to Pulmonary Endothelium. Kazuo Maruyama, Eric Holmberg, et al. Journal of Pharmaceutical Sciences, vol. 79, No. 11. Nov. 1990. pp. 978-984.
Highly Efficient Immunoliposomes Prepared with a Method Which Is Compatible with Various Lipid Compositions. Eric Holmberg, Kazuo Maruyama et al. Biochemical & Biophysical Research Communications, vol. 165, No. 3, Dec. 29, 1989, pp. 1272-1278.
ph-Sensitive Immunoliposomes as an Efficient and Target-Specific Carrier for Antitunor Drugs. Jerome Connor and Leaf Huang. Cancer Research, vol. 46. Jul. 1986. pp. 3431-3435.
Cytotoxicity of Diphtheria Toxin A Fragment to Toxin-Resistant Murine Cells Delivered by pH-Sensitive Immunoliposomes. David Collins and Leaf Huang. Cancer Research. vol. 47. Feb. 1, 1987. pp. 735-739.
Lipid Polymorphism and the Functional Roles of Lipids in Biological Membranes. P.R. Cullis and B. De Kruijff. Biochimica et Biophysica Acta, vol. 599. 1979. pp. 339-420.
C. Wang et al. PNAS 84 (Nov. 1987) 7851-5.
K. Suda et al. Neuro Report 5 (14) ('94) 1749-51 (Abstract).
E. Holmberg et al. BBRC 201(2) (194) 888-93 (Abstract).
Y. Takamiya et al. J. Neurosurgery 79(1) (93) 104-110 (Abstract).
E. Daneiger et al. PNAS 86(21) (89) 8565-69 (Abst.).
R. Fabian Neurology 40 (3 Pz. 1) (90) 419-22 (Abst).
B. Niggeman et al. Neurosci. Let I. 51(2) (84) 231-4 (Abst.).
E. Daneiger et al. PNAS 86: 8565-9 ('89).
Y. Takamiya J. Neurosurg. 79: 104-110 ('93).
R. Fabian Neurology 40:419-22 ('90).
B. Niggeman Neurosci. Lett. 51:231-4 ('84).
H. San et al. Human Gene Therapy 4:781-8 ('93).
P. Hug et al. B. B. Acta 1097:177 ('91).
P. Felgner et al. PNAS 84:7413-17 ('87).
J. Felgner et al. J.B.C. 269(4) 2550-61 ('94).
M. Schappe et al. Cancer Res. 51(18):4986-93 ('91).
E. Geisert et al. Neurosci. Lett. 133(2)262-6 ('91).
I. Solodin et al. Biochem. 34:13537-44 ('95).
E. Holmberg, et al., Journal of Lipsome Research 1(4) (1990), pp. 393-406.
Rories Charles C. P.
Spinal Cord Society
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