Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1987-05-12
1991-03-05
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
530390, 530391, 530810, 530812, 424 8591, 424 9, 514 2, 514 8, 514 21, 514885, C07K 1528, A61K 3900
Patent
active
049979132
ABSTRACT:
Novel pH-sensitive immunoconjugates which dissociate in low-pH tumor tissue, comprising a chemotherapeutic agent and an antibody reactive with a tumor-associated antigen are described. The chemotherapeutic agent is coupled to the antibody by a link which is unstable in low pH. The link may comprise a spacer consisting of a polyamino acid. Representative antibodies for use in these immunoconjugates include monoclonal antibodies which are not internalized by tumor cells.
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Hellstrom Ingegerd E.
Hellstrom Karl E.
Lavie Efraim
Draper Garnette D.
Mandel SaraLynn
Oncogen
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