pH-sensitive block copolymers for pharmaceutical compositions

Details pH-sensitive block copolymers for pharmaceutical compositions pH-sensitive block copolymers for pharmaceutical compositions

2006-08-22

2006-08-22

Kishore, Gollamudi S. (Department: 1615)

Drug, bio-affecting and body treating compositions

Designated organic nonactive ingredient containing other...

Aftertreated solid synthetic organic polymer

C514S772000, C514S772300, C424S450000, C424S489000

Reexamination Certificate

active

07094810

ABSTRACT:
The present invention relates to a pharmaceutical composition of a biologically active agent and a block copolymer composed of a poly(ethylene oxide) forming hydrophilic segment and a poly(butyl (alkyl)acrylate-co-(alkyl)acrylic acid) that is capable of forming supramolecular assemblies or micelles under favourable conditions. The supramolecular assemblies or micelles formed from said polymers associate or dissociate reversibly upon changes in the environmental pH. The pharmaceutical compositions of the present invention contain hydrophobic drugs, cations or polycationic compounds, which can be delivered to the body by oral route or other routes of administration.

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