pH independent extended release pharmaceutical formulation

Details pH independent extended release pharmaceutical formulation pH independent extended release pharmaceutical formulation

2000-01-25

2000-11-21

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

5147723, 514781, A61K 3119, A61K 4730, A61K 4700

Patent

active

061504106

ABSTRACT:
Pharmaceutical formulations of acidic pharmacologic agents which demonstrate improved uniformity of release over the wide range of pH values encountered between the stomach and intestinal tract comprise an acidic pharmacologic agent dissolved or dispersed in a matrix comprising about 10 weight percent to about 40 weight percent of a a neutral water-swellable hydrophilic polymer and 20 weight percent to about 50 weight percent of an acid-soluble polymer which swells in water at pH values above about 5. A particularly preferred formulation comprises divalproex sodium. Also disclosed are pre-tablet granulations and process for preparing both the pre-tablet granulation and the tablet unit dosage form.

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