Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Solid synthetic organic polymer
Patent
1997-04-23
1999-09-21
Kulkosky, Peter F.
Drug, bio-affecting and body treating compositions
Designated organic nonactive ingredient containing other...
Solid synthetic organic polymer
528392, 528423, A61K 4734, C08G 6800
Patent
active
059555092
ABSTRACT:
The present invention relates to the use of poly(vinyl N-heterocycle)-block-poly(alkylene oxide) copolymers in micelle containing pharmaceutical formulations. The copolymers advantageously respond to pH differences in the environment to which they are exposed forming micelles at higher pH values. The micelles, which comprise a therapeutic compound and a copolymer, deliver drug in a pH dependent manner.
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Martin Thomas J.
Webber Stephen E.
Board of Regents , The University of Texas System
Kulkosky Peter F.
Mayfield Denise L.
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