pH controlled fermentation process for pseudomonic acid...

Details pH controlled fermentation process for pseudomonic acid... pH controlled fermentation process for pseudomonic acid...

2002-06-21

2008-10-21

Marx, Irene (Department: 1651)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

C435S123000, C435S117000, C435S136000, C435S252300

Reexamination Certificate

active

07439045

ABSTRACT:
An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing aPseudomonassp. strain in a submerged medium at a temperature within about 20-30° C. The pH of the fermentation medium is regulated to be at about 5.5-6.0 by feeding the fermentation medium with an assimilable carbon source, a mineral salt, or an acidic/alkali solution. Accordingly, the resulting fermentation broth contains an increased yield of highly purified pseudomonic acid A as the main component. The pseudomonic acid B as an impurity in the fermentation broth is significantly decreased.

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