PGRP-L polynucleotides, polypeptides, and antibodies

Details PGRP-L polynucleotides, polypeptides, and antibodies PGRP-L polynucleotides, polypeptides, and antibodies

2005-02-01

2005-02-01

Graser, Jennifer E. (Department: 1645)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C424S133100, C424S139100, C424S141100, C424S142100, C424S152100, C424S130100, C530S387100, C530S387300, C530S387900, C530S388100, C530S388150, C530S388700, C435S326000

Reexamination Certificate

active

06849413

ABSTRACT:
The present invention relates to novel human and murine proteins called PGRP-L, and isolated polynucleotides encoding these proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.

REFERENCES:
patent: WO-0005367 (2000-02-01), None
Kibardin. Submitted. May 1999. Genbank Accession No. Q9QXZ2.*
Wang et al., “Human Peptidoglycan Recognition Protein-L is an N-Acetylmuramoyl-L-alanine Amidase,”J. Biol. Chem. 278(49):49044-49052 (Dec. 5, 2003).
Liu et al., “Peptidoglycan Recognition Proteins,”J. Biol. Chem. 276(37):34686-34694 (Sep. 14, 2001).
Hillier et al., GenBank Accession No. AA121766, “zn95a11.r1 Stratagene fetal retina 937202Homo sapienscDNA clone IMAGE:565916 5' similar to contains L1.b1 L1 repetitive element;, mRNA sequence”. (Feb. 2, 1997).
NCI-CGAP, GenBank Accession No. AA829438, “od27d10.s1 NCI_CGAP_GCB1Homo sapienscDNA clone IMAGE;1369171 3' similar to contains L1.t3 L1 repetitive element;, mRNA sequence”. (Mar. 31, 1998).
De Pauw et al., “Characterization of human serum N-acetylmuramyl-L-alanine amidase purified by affinity chromatography,”Protein Expr. Purif. 6(3):371-378 (Jun. 1995).
Ochiai et al., “A Pattern Recognition Protein for Peptidoglycan,”J. Biol. Chem. 274(17):11854-11858 (Apr. 23, 1999).
Kang et al., A peptidoglycan recognition protein in innate immunity conserved from insects to humans,Proc. Natl. Acad. Sci. USA95:10078-10082 (Aug. 1998).
Rehman et al., “Cloning and expression of peptidoglycan recognition protein (PGRP) in the brain and spleen of rattus norvegicus,”Society for Neuroscience Abstracts, 25(1-2):1445 (1999), abstract No. 580.4.
International Search Report for International Application No. PCT/US00/22877 dated Feb. 7, 2001.

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