PGD2 receptor antagonistic pharmaceutical compositions

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S448000, C514S469000, C549S057000, C549S467000

Reexamination Certificate

active

06933317

ABSTRACT:
Compounds of the general formula (I) which are metabolically stable and have an antagonistic activity against PGD2receptor: wherein Y is bicyclic ring; R1is optionally substituted heteroaryl; R2is hydrogen, etc.; R3is —CH2—CH2—CH2—CH2—CH═CH—COOR4, —CH2—CH2—CH2—CH2—X1—CH2—COOR4, —CH2—CH═CH—CH2—X1—CH2—COOR4or —CH2—CH2—CH2—COOR4; R4is hydrogen, etc.; X1is —O—, etc.

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