PF4A receptor

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 691, 530300, 530325, 530326, 530350, 536 235, C07K 704, C07K 14705

Patent

active

060874759

ABSTRACT:
cDNAs encoding a class of receptors, including the IL-8 receptors, have been identified in human tissue. Recombinantly produced PF4ARs are used in the preparation and purification of antibodies capable of binding to the receptors, and in diagnostic assays. The antibodies are advantageously used in the prevention and treatment of inflammatory conditions.

REFERENCES:
patent: 5374506 (1994-12-01), Murphy
patent: 5543503 (1996-08-01), Chuntharapai et al.
Antibodies: A Laboratory Manual (Chapter 5), Harlow and Lane, eds., Cold Spring Harbor Laboratory pp. 72-76 (1988).
Beckmann et al., "Molecular characterization of the interleukin-8 receptor" Biochem. & Biophys. Res. Comm. 179(2):784-789 (Sep. 16, 1991).
Besemer et al., "Specific Binding, Internalization, and Degradation of Human Neutrophil Activating Factor by Human Neutrophil Activating Factor by Human Polymorphonuclear Leukocytes" Journal of Biological Chemistry 264:17409-17415 (1989).
Boulay et al., "Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl eptide receptor cDNA" Biochem. Biophys Res. Comm. 168(3):1103-1109 (1990).
Broaddus et al., "Interleukin-8 is a major neutrophil chemotactic factor in pleural liquid of patients with empyema" Amer. Rev. Resp. Disease 146:825-830 (1992).
Chuntharapai et al., "Generation and characterization of monoclonal antibodies (mAbs) to human IL 8 receptor A" J. Immunol. (abstract #708) 150(8(2)):126A (May 1993).
Chuntharapai et al., "Neutralizing monoclonal antibodies to human IL-8 receptor A map to the NH.sub.2 -terminal region of the receptor" J. Immunol. 152(4):1783-1789 (1994).
Clark-Lewis et al., "Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu-Leu-Arg" Proc. Natl. Acad. Sci. USA 90(8):3574-3577 (Apr. 15, 1993).
Clark-Lewis et al., "Structure-Activity Relationships of Interleukin-8 Determined Using Chemically Synthesized Analogs" Journal of Biological Chemistry 266(34):23128-23134 (1991).
D'Andrea et al., "Expression Cloning of the Murine Erythropoietin Receptor" Cell 57: 277-285 (1989).
Dixon et al., "Structural features required for ligand binding to the A-adrenergic receptor" EMBO Journa l6(11):3269-3275 (1987).
Dixon, et al., "Structure-Function Analysis of the Beta-Adrenergic Receptor" Cold Spring Har. Sym. Quant. Biol. 53:487-497 (1988).
Federsppiel et al., "Molecular cloning of the cDNA and chromosoal localization of the gene for a putative seven-traqnsmembrane segment (7-TMS) receptor isolated from human spleen" Genomics 16:707-712 (1993).
Feng, Yu et al., "HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor" Science 272:872-877 (1996).
Gayle III et al., "Importance of the Amino Terminus of the Interleukin-8 Receptor in Ligand Interactions" Journal of Biological Chemistry 268(10):7283-7289 (1993).
Lee et al., "Characterization of Two High Affinity Human Interleukin-8 Receptors" Journal of Biological Chemistry 267(23):16283-16287 (1992).
Gerard & Gerard, "The chemotactic receptor for human C5a anaphylatoxin" Nature 349:614-617 (1991).
Grob et al., "Characterization of a Receptor for Human Monocyte-derived Neutrophil Chemotaqcic Factor/Interleukin-8" Journal of Biological Chemistry 265(14):8311-8316 (1990).
Hammond et al., "Generation of neutralizing antibodies to human interleukin-8 (IL8) receptors" J. Cell Biochem. (Suppl. 18B) 318:Abstract #0108 (1994).
Harada et al. Gene 142:297-300 (1994).
Hebert et al., "Endothelial and Leukocyte Forms of IL-8: Conversion by Thrombin and Interactions with Neutrophils" J. Immunol. 145(9):3033-3040 (Nov. 1, 1990).
Hebert et al., "Partial functional mapping of the human interleukin-8 type A receptor" Journal of Biological Chemistry 268(25):18549-18553 (1993).
Hebert et al., "Scanning Mutagenesis of Interleukin-8 Identifies a Cluster of Residues Required for Receptor Binding" Journal of Biological Chemistry 266(28):18989-18944 (1991).
Herzog et al., "Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation" DNA and Cell Biology 12(6):465-471 (1993).
Holmes et al., "Structure and Functional Expression of a Human Interleukin-8 Receptor" Science 253(5025):1278-1280 (Sep. 13, 1991).
Jazin et al., "A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells" Regulatory Peptides 47:247-258 (1993).
Kahan et al., Current Opinion in Immunology 4:553-560 (1992).
Koch et al., "Interleukin-8 as a Macrophage-Derived Mediator of Angiongenesis" Science 258:1798-1801 (1992).
Koch et al., "Synovial tissue macrophage as a source of the chemotactic cytokine IL-8" J. Immunol. 147(7):2187-2195 1991.
Kubo et al., "Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor" Nature 323:411-416 (1986).
LaRosa et al., "Amino terminus of the interleukin-8 receptor is a major determinant of receptor subtype specificity" Journal of Biological Chemistry 267(35):25402-25406 (1992).
Lee et al., "Characterization of Complementary DNA Clones Encoding the Rabbit IL-8 Receptor" Journal of Immunology 148(4):1261-1264 (Feb. 15, 1992).
Lerner, R.A., "Tapping the Immunological Repertoire to Produce Antibodies of Predetermined Specificity" Nature 299:592-596 (Oct. 1982).
Lindley et al., "NAP-1/IL-8 in Rheumatoid Arthritis" Advances in Experimental Medicine and Biology (Chemotactic Cytokines: Biology of the Inflammatory Peptide Supergene Family), Westwick, J. et al. (eds) vol. 305:147-156 (1991).
Loetscher et al., "Cloning of a human seven-transmembrane domain receptor, LESTR, that is highly expressed in leukocytes" Journal of Biological Chemistry 269(1):232-237 (1994).
Mahida et al., "Enhanced synthesis of neutrophil-activating peptide-I/interleukin-8 in active ulcerative colitis" Clinical Science 82:273-275 (1992).
Moser et al., "Interleukin-8 Antagonists Generated by N-terminal Modification" Journal of Biological Chemistry 268(10):7125-7128 (1993).
Murphy and Tiffany, "Cloning of complementary DNA encoding a functional human interleukin-8 receptor" Science 253(5025):1280-1283 (Sep. 13, 1991).
Nomura, H. et al., "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors" International Immunology 5(10):1239-1249 (1993).
Oppenheim et al., "Properties of the novel proinflammatory supergene intercine cytokine family" Annu. Rev. Immunol. 9:617-648 (1991).
Peralta et al., "Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetycholine receptors" EMBO Journal 6:3923-3929 (1987).
Prado et al. Journal of Biological Chemistry 269(17):12391-12394 (Apr. 29, 1994).
Quan, J.M. et al., "Antibodies against the N-terminus of IL-8 receptor A inhibit neutrophil chemotaxis" Biochem.& Biophys. Res. Comm. 219:405-411 (1996).
Ramachandran et al., "The Structural and Functional Interrelationships of Muscarinic Acetylcholine Receptor Subtypes" Bioessays 10:54-57 (1989).
Samanta et al., "Identification and characterization of specific receptors for monocyte-derived neutrophil chemotactic factor (MDNCF) on human neutrophils" Journal of Experimental Medicine 169:1185-1189 (1989).
Saragovi et al., "The Murine Interleukin 2 Receptor: Irreversible Cross-Linking of Radiolabeled Interleukin 2 to High Affnity Interleukin 2 Receptors Reveals a Noncovalently Associated Subunit" J. Immunol. 139(6):1918-1926 (Sep. 15, 1987).
Sevier et al., "Monoclonal Antibodies in Clinical Immunology" Clinical Chemistry 27(11):1797-1806 (1981).
Sims et al., "cDNA Expression Cloning of the I1-1 Receptor, a Member of the Immunoglobulin Superfamily" Science 241:585-589 (1988).
Sticherling et al., "Production and Characterization of Monoclonal Antibodies Against the Novel Neutrophil Activating Peptide NAP/IL-8" J. Immunol. 143(5):1628-1634 (Sep. 1, 1989).
Strader et al., "Structural basis of A-adrenergic receptor function" FASEB 3:1825-1832 (1989).
Tayl

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

PF4A receptor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with PF4A receptor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and PF4A receptor will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-543298

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.