Petide antidementia and nootropic agents

Details Petide antidementia and nootropic agents Petide antidementia and nootropic agents

1989-08-14

1993-01-19

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 514 18, 530315, 530329, 530330, A61K 3702, C07K 510, C07K 706

Patent

active

051807122

ABSTRACT:
A peptide having one of the following formulae (I), (II), (III) and (IV): ##STR1## or its functional derivatives, and a pharmaceutically acceptable salt thereof are disclosed. These peptides have a nootropic effect and are effective as antidementia agents.

REFERENCES:
patent: 4487765 (1984-12-01), de Wied
Burbach et al., A Major Metabolite of Arginme Vasopressin in the Brain is a Highly Potent Neuropeptide, Science 221: 1310-1312, (1983).
Stedman, Stedman's Medical Dictionary, 24th Ed. (1982).
Psychopharmacology (1982) 78:104-111, "Effects of the Novel Compound Aniracetam (Ro 13-5057) Upon Impaired Learning and Memory in Rodents".
Recl. Trav. Chim. Pays-Bas 103, 68-74 (1984), "Synthesis of Fragments of Arginine Vasopressin and Oxytocin Containing a Cystine Residue . . . ".
Collection Czechoslovak Chem. Commun. (vol. 53) (188), "Formation of Open-Chain Asymmetrical Cystine Peptides on a Solid Support . . . ".

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