Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof
Reexamination Certificate
2006-05-02
2006-05-02
Housel, James (Department: 1648)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Virus or component thereof
C424S204100, C424S093100, C435S005000, C435S091330, C435S235100, C435S236000, C435S237000, C435S239000, C536S023720
Reexamination Certificate
active
07037508
ABSTRACT:
The present invention is directed to attenuated pestivirus mutants, which have a reduced ability to replicate as exhibited by a small plaque size. The mutations are in the 5′ nontranslated region of the viral genome. These mutant viruses are useful as live vaccines in the control of bovine viral diarrhea, border disease and classical swine fever.
REFERENCES:
patent: 0 965 639 (1999-12-01), None
patent: WO 99 55366 (1999-11-01), None
Frolov et al. RNA. 1998; 4: 418-435.
Grooms et al. Journal of Veterinary Diagnostic Investigation. 1998; 10 (2): 130-134, abstract only.
Becher et al. Journal of Virology. 1998; 72 (6): 5165-5173.
Thiel et al. “ Pestiviruses”, Fields Virology, 3rd edition. 1996. Lippencott-Raven, Philadelphia: 1059-1073.
Chon SK et al: “Genetic analysis of the internal ribosome entry segment of Bovine Viral Diarrhea Virus” Virology, vol. 251, No. 2, Nov. 1998, pp. 370-382.
Becher P et al: Mutations in the 5' nontranslated region of Bovine Viral Diarrhea Virus result in altered growth characteristics, Journal of Virology, vol. 74, No. 17, Sep. 2000, pp. 7884-7894.
Becher Paul P.
Orlich Michaela M.
Thiel Heinz-Jürgen
Akzo Nobel NV
Blackstone William M.
Foley Shanon
Housel James
Milstead Mark W.
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