Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2000-06-01
2001-10-02
Robinson, Allen J. (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S422000, C514S427000
Reexamination Certificate
active
06297263
ABSTRACT:
The present invention relates to pest control compositions which contain an active compound combination of certain agonists or antagonists of the nicotinic acetylcholine receptors of insects together with fungicides, their preparation and their use for the control of plant pests.
Agonists or antagonists of the nicotinic acetylcholine receptors of insects are known, for example from the following publications:
European Published Specifications No. 464 830, 428 941, 425 978, 386 565, 383 091, 375 907, 364 844, 315 826, 259 738, 254 859, 235 725, 212 600, 192 060, 163 855, 154 178, 136 636, 303 570, 302 833, 306 696, 189 972, 455 000, 135 956, 471 372, 302 389; German Published Specifications No. 3 639 877, 3 712 307; Japanese Published Specifications No. 03 220 176, 02 207 083, 63 307 857, 63 287 764, 03 246 283, 04 9371, 03 279 359, 03 255 072; U.S. Pat. Nos. 5,034,524, 4,948,798, 4,918,798, 4,918,086, 5,039,686, 5,034,404; PCT Applications Nos. WO 91/17 659, 91/4965; French Application No. 2 611 114; Brazilian Application No. 88 03 621.
The methods, processes, formulae and definitions described in these publications, and also the specific preparations and compounds described therein, are expressly referred incorporated herein.
Fungicidal active compounds, such as azole derivatives, aryl benzyl ethers, benzamides, morpholine compounds and other heterocycles are known (cf. K. H. Büchel “Pflanzenschutz und Schädlingsbekämpfung [Crop protection and pest control]”, pages 140 to 153, Georg Thieme-Verlag, Stuttgart 1977, EP-OS (European Published Specification) 0 040 345, DE-OS (German Published Specification) 3 324 010, DE-OS (German Published Specification) 2 201 063, EP-OS (European Published Specification) 0 112 284, EP-OS (European Published Specification) 0 304 758, and DD-PS (German Democratic Republic Patent Specification) 140 412).
Mixtures of certain nitromethylene derivatives with fungicidal active compounds and their use as compositions for the control of pests in crop protection are already known (U.S. Pat. No. 4,731,385; JP-OS (Japanese Published Specifications) 63-68507, 63/68505, 63/72 608, 63/72 609, 63/72 610). Mixtures of certain open-chain nitromethylenes and nitroguanidines with fungicides are already known (JP-OS (Japanese Published Specification) 30 47 106; U.S. Pat. No. 5,181,587).
Mixtures of cyclopropylcarboxamides with certain nitromethylenene or nitroguanidine derivatives are already known (JP-OS (Japanese Published Specification) 3 271 207;
Mixtures of inter alia imidacloprid- and fungicidal active compounds for use in material protection and against termites, but not for use against plant-damaging pests, are already known (EP-OS (European Published Specification) (Nit 259)). Mixtures of imidacloprid and azolylmethylcycloalkanes, in particular triticonazole, are known from EP-OS (European Published Specification) 545 834.
However, nothing is yet known about nitroguanidine derivatives and fungicides other than cyclopropylcarboxamides and triticonazole influencing each other so favourably in over action that, while being well tolerated by plants, they can be used with outstanding effect as compositions for the control of plant pests.
The present invention relates to plant pest control compositions which contain compounds of the the general formula (I)
in which
x represents —CH═ or ═N—,
E represents an electron-withdrawing radical, in particular nitro or cyano,
R represents optionally substituted hetarylalkyl,
A represents hydrogen, alkyl, or a bifunctional group which is linked to the radical Z,
Z represents alkyl, —NH, alkyl, —N(alkyl)
2
or a bifunctional group which is linked to the radical A,
in mixtures with fungicidal active compounds, excluding cyclopropylcarboxamide derivatives and azolylmethylcycloalkanes.
Preferably, the invention relates to plant pest control compositions which contain compounds of the formula (I) in which the radicals have the following meaning:
X represents ═CH— or ═N—,
E represents NO
2
or CN,
R represents hetarylmethyl, hetarylethyl having up to 6 ring atoms and N, O, S, in particular N, as heteroatoms.
In particular there may be mentioned thienyl, furyl, thiazolyl, imidazolyl, pyridyl, which are optionally substituted.
Preferred examples of substituents are:
alkyl having preferably 1 to 4, in particular 1 or 2 carbon atoms, such as methyl, ethyl, n- and i-propyl and n-, i- and t-butyl; alkoxy having preferably 1 to 4, in particular 1 or 2 carbon atoms, such as methoxy, ethoxy, n- and i-propyloxy and n-, i- and t-butyloxy; alkylthio having preferably 1 to 4, in particular 1 or 2 carbon atoms, such as methylthio, ethylthio, n- and i-propylthio and n-, i- and t-butylthio; haloalkyl having preferably 1 to 4, in particular 1 or 2 carbon atoms and preferably 1 to 5, in particular 1 to 3 halogen atoms, wherein the halogen atoms are identical or different and wherein the halogen atoms are preferably fluorine, chlorine or bromine, in particular fluorine, such as trifluoromethyl; hydroxyl; halogen, preferably fluorine, chlorine, bromine and iodine, in particular fluorine, chlorine and bromine; cyano; nitro; amino; monoalkyl- and dialkylamino having preferably 1 to 4, in particular 1 or 2 carbon atoms per alkyl group, such as methylamino, methylethylamino, n- and i-propylamino and methyl-n-butylamino;
A represents hydrogen, C
1-4
alkyl, in particular methyl or ethyl,
Z represents C
1-4
alkyl, in particular ethyl or methyl, —NH(C
1-4
alkyl), —N(C
1-4
alkyl) or
A and Z, form together with the atoms to which they are bonded, form a saturated or unsaturated heterocyclic ring. The heterocyclic ring may contain a further 1 or 2 identical or different heteroatoms and/or heterogroups. Preferably, heteroatoms are oxygen or nitrogen and heterogroups are N-alkyl, the alkyl of the N-alkyl group containing preferably 1 to 4, in particular 1 or 2 carbon atoms. Examples of alkyl include methyl, ethyl, n- and i-propyl and n-, i- and t-butyl. The hesterocyclic ring contains 5 to 7, preferably 5 or 6 ring members.
Examples of the heterocyclic ring include pyrrolidine, piperidine, thiazolidine, piperazine, imidazoliudine, hexamethyleneimine, hexahydro-1,3,5-triazine, morpholine, which may optionally be substituted, preferably by methyl.
Most preferred are compounds of the general formulae (I) and (Ib)
in which
n represents 1 or 2,
Subst. represents one of the abovementioned substituents, in particular halogen, especially chlorine,
A and Z have the abovementioned preferred meanings,
Specifically, the following compounds may be mentioned:
Fungicides in the novel compositions for the control of plant pests are for example:
(1) Azole derivatives of the formula
(2) Azole derivatives of the formula
(3) The azole derivative of the formula
(4) The compound
S
x
(V)
(5) Azole derivative of the formula
(6) Heterocycles of the formula
(7) Compound of the formula
(8) Compound of the formula
(9) Compound of the formula
(10) Compound of the formula
(11) Compound of the formula
(12) Compound of the formula
(13) Compounds of the formula
(14) Compounds of the formula
(15) Compounds of the formula
(16) Compound of the formula
(17) Compound of the formula
(18) Compound of the formula
(19) Compound of the formula
(20) Compound of the formula
(21) Compound of the formula
(22) Compound of the formula
(23) Compound of the formula
(24) Compounds of the formula
(25) Compound of the formula
(26) Compound of the formula
(27) Compound of the formula
(28) Compound of the formula
(29) Compound of the formula
(30) Compound of the formula
(31) Compound of the formula
(32) Compounds of the formula
(33) Compound of the formula
(34) Compound of the formula
(35) Compound of the formula
(36) Compound of the formula
(37) Compound of the formula
(38) Compounds of the formula
in which
R
15
and R
16
, independently of each other, represent hydrogen, halogen, methyl or phenyl, and
R
17
represents hydrogen or methyl,
(39) 8-
t
Butyl-2-(N-ethyl-N-n-propylamino)-methyl-[4]-dioxaspiro[4.5]d
Andersch Wolfram
Dehne Heinz-Wilhelm
Dutzmann Stefan
Erdelen Christoph
Hartwig Jurgen
Bayer Aktiengesellschaft
Gil Joseph C.
Robinson Allen J.
Zurcher Jackie Ann
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