Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Reexamination Certificate
2000-04-24
2001-01-23
Dodson, Shelley A. (Department: 1616)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
C514S537000
Reexamination Certificate
active
06177465
ABSTRACT:
FIELD OF THE INVENTION
The present invention relates to pesticidal compositions.
BACKGROUND ART
It is known that 2-methoxycarbonyl-4-chlorotrifluoromethanesulfonaniiide can be used as an active ingredient of an insecticidal/acaricidal coosition in Japanese Laid-open Patent Nos. sho-57-156407A and hei-8-319202A. However, its insecticidal/acaricidal effect may be insufficiently given when used as total release aerosol formulations or smoking formulations. Especially, the effect against Acaridae, particularly copra mite (
Tyrophagus putrescentiae
), that is an important object because of alergen, may be low.
SUMMARY OF THE INVENTION
The present invention provides a pesticidal composition comprising 2-methoxycarbonyl-4-chlorotrifluoromethanesulfonanilide of the formula
and at least one ester compound selected fron the group of specific ester compounds, which has an extremely good pesticidal activity and especially shows an excellent effect in a formulation of a total release aerosol composition, foaming composition or smoking composition.
The present pesticidal composition comprises 2-methoxycarbonyl-4-chlorotrifluoromethanesulfonanilide (hereinafter referred to as the present compound) and at least one ester compound (hereinafter referred to as the present ester) selected from the group consisting of di-C
2-8
-alkyl C
4-10
-alkanedicarboxylate, tri-C
2-4
-alkyl citrate, tri-C
2-4
-alkyl O-acetylcitrate and C
8-18
-fatty acid ester.
DETAILED DESCRIPTION OF THE INVENTION
In the present invention, preferable examples of the di-C
2-8
-alkyl C
4-10
-alkanedicarboxylate include di-C
3-8
-alkyl adipate, di-C
3-8
-alkyl succinate and di-C
2-8
-alkyl sebacate. Preferable examples of the C
8-18
-fatty acid ester include glycerin triester of C
8-18
-fatty acid and C
2-8
-alkyl ester of C
8-18
-fatty acid.
Typical examples of the present ester include dibutyl adipate, diisobutyl adipate, dipropyl succinate, diethyl sebacate, triethyl citrate, triethyl O-acetylcitrate, tributyl O-acetylcitrate, glyceryl tri(2-ethylhexanoate), isopropyl myristate and isopropyl isostearate.
The weight ratio of the present compound and the present ester in the present composition is usullly in the range of fran 1:1 to 1:50.
The content of the present compound in the present composition is usually 0.01 to 20% by weight, but depends on the formulation type. In aerosol formulations, foaming formulations or smoking formulations, the content of the present compound is usually 0.3 to 10% by weight. In liquid formulations such as oil formulations and emulsifiable concentrates, said content is usually 0.1 to 20% by weight. Further, in dusts, said content is usually 0.01 to 5% by weight.
In the case that the present composition is a formulation of oil formulations, emulifiable concentrates, suspensible concentrates, dusts, granules and so on, the formulation can further contain a solid carrier or an auxiliary agent such as a surfactant, dispersant, wetting agent, thickner, antioxidant, UV-absorber and organic solvent. Said solid carriers are exemplified by talc, bentonite, clay, kaolin, diatomaceous earth, silica, vermiculite and perlite. Said organic solvents are exemplified by aromatic hydrocarbons (e.g., xylene, methylnaphthalene, phenylxylylethane, alkylbenzene), ketones (e.g., acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone, isophorone), alcohols (e.g., methanol, ethanol, isopropyl alcohol, hexanol, benzyl alcohol, ethylene glycol, propylene glycol, 3-methoxy-3-methyl-1-butanol), 3-methoxy-3-methyl-1-butyl acetate, N-methyl-2-pyrrolidone and propylene carbonate.
In the case that the present composition is an aerosol formulation, the present composition comprises the present compound, the present ester, a saturated hydroarbon solvent and a propellant. The content of the components is usually 0.5 to 10% by weight, 0.5 to 20% by weight, 3 to 59% by weight and 40 to 90% by weight respectively.
For controlling indoor mites, especially house dust mites, it is very effective to utilize a total release aerosol formulation. Total release aerosol is an aerosol for applying all the contents in a short period to a closed room. An actuator for total release is fitted to the aerosol container, wherein the actuator has a means for keeping a spray button pushed after the button is once pushed.
The saturated hydrocarbon solvent may be a straight-chain or branched aliphatic hydrocarbon, an alicyclic hydrocarbon or a mixture thereof. Examples of the propellant include propane, n-butane, isobutane, dimethyl ether and mixtures thereof. In these propellants, dimethyl ether is preferably utilized. Compressed gas such as nitrogen, carbon dioxide, air and so on, may be further charged for increasing the inner pressure to make the total release easy. The content of the propellant is preferably 60 to 90% by weight in the aerosol formation and the inner pressure of the aerosol container is usually 3 to 6 kg/cm
2
of gauge pressure at 20° C., when the aerosol is a total release aerosol.
A diameter of a sprayed mist can be varied according to a sort of aerosol valve, weight ratio of liquid/propellant, inner pressure and terminal orifice size of actuator. And it is preferable to utilize an aerosol valve for making the volume median diameter 5 to 30 &mgr;m at 30 cm from the termil orifice when the spray speed of the contents is 1 to 3 g/sec.
It is easy to apply the present cooposition to a surface or inner of carpet and mat, when the present composition is an aerosol formilation.
In the case that the present composition is a foaming formulation, the present composition cmprises the present compound, the present ester and an organic foaming agent. The content of the components is usually 0.5 to 10% by weight, 1 to 30% by weight and 60 to 97.5% by weight respectively.
Examples of the organic foaming agent include azodicarbonamide, p-toluenesulfonylhydrazide, benzenesulfonylhydrazide, azobisisobutyronitrile, 2,2′-azobisisobutyramide, 2-(carbamoylazo)isobutyronitrile, methyl-2,2′-azobisisobutyrate, 2,4-bis(azosulfonetoluene), 1,1′-azobiscyclohexanecarbonitrile and dinitrosopentamethylenetetramine. The present foaming formulation can further contain a foaming adjusting agent such as zinc oxide, magnesium oxide, calcium stearate, zinc stearate and so on.
The present foaming formulation is utilized by heating. The heating source may be a chemical reaction of calcium oxide with water or electric heater.
The present foaming formulation can be granules, which are usually prepared by kneading the present compound, the present ester, an organic foaming agent and so on with water, extruded, dried and molded to 1 to 5 mm granules. For making the molding easy, it is preferable to add a binder to the formulation. Said binder may be methylcellulose, hydroxymethylcellulose, hydroxypropylceliulose, water soluble starch and so on. The present foaming formulation can also be prepared by making granules without the present compound or the present ester and then adding the present compound and the present ester or their solution dissolved with a volatile solvent such as acetone, dichloromethane and so on, if necessary.
The present foaming formulations are usually charged in a container such as a metal container and utilized by heating the container fran outside by the above-mentioned heating source.
In the case that the present composition is a smoking formulation, the present composition comprises the present compound, the present ester, nitrocellulose, an organic foaming agent and an oxidizing agent. The content of the components is usually 0.3 to 10% by weight, 0.3 to 20% by weight, 2 to 20% by weight, 5 to 30% by weight, and 5 to 30% by weight respectively.
In the present smoking formulation, nitrocellulose may be used as a solid solution mixed with a plasticizer such as dibutyl phthalate and tricresyl phosphate or as celluloid.
Examples of the oxidizing agent include perchlorate salts such as ammonium perchlorate, potassium perchlorate and sodium perchlorate, and chlorate salts such as potassium chlorate.
The present smoking
Dodson Shelley A.
Pryor Alton
Sughrue Mion Zinn Macpeak & Seas, PLLC
Sumitomo Chemical Company Limited
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