Pertussis toxin mutants, bordetella strains capable of...

Details Pertussis toxin mutants, bordetella strains capable of... Pertussis toxin mutants, bordetella strains capable of...

1994-06-17

2008-09-23

Kam, Chih-Min (Department: 1656)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

C424S254100, C424S185100, C530S350000, C514S002600, C514S012200

Reexamination Certificate

active

07427404

ABSTRACT:
New pertussis toxin (PT) mutants are described being immunologically active and having reduced or no toxicity, characterized in that at least one of the aminoacid residues Glu129, Asp11, Trp26, Arg9, Phe50, Asp1, Arg13, Tyr130, Gly86, Ile88, Tyr89, Tyr8, Gly 44, Thr53 and Gly80 or subunit's 1 aminoacid sequence is deleted and substituted by a different aminoacid residue selected in the group of natural aminoacids; Bordetella strains capable of providing and secreting said PT mutants and means and methods for obtaining them are also described.The Bordetella strains and the PT mutants produced by them are particularly suitable for the preparation of effective cellular and acellular antipertussis vaccines.(FIG. 1)

REFERENCES:
patent: 4883761 (1989-11-01), Keith et al.
patent: 5000952 (1991-03-01), Steinman et al.
patent: 5085862 (1992-02-01), Klein et al.
patent: 6713072 (2004-03-01), Pizza et al.
patent: 0232229 (1987-08-01), None
Singleton etal. in: Dictionary of Microbiology and Molecular Biology. John Wiley & Sons. Chichester, England. p. 573.
Pizza etal 1988. Proc. Natl Acad. Sci. USA, 85, 7521-7525.
Burnette etal. 1988. Science, 242, 72-74.
Barbieri etal, 1988. Infec. Immun, 56, 1934-1941.
Cieplak etal. 1988. Proc. Natl. Acad. Sci. USA. 85,4667-4671.
Stibitz etal. 1986. Gene 50, 133-140.
Arico etal. 1987. J. Bacteriol. 169, 2847-2853.
Nicosia etal. 1986. Proc. Natl. Acad. Sci. USA. 83, 4631-4635.
Barto Ioni etal, 1988. Bio/Technol. 6, 709-712.
Pizza etal 1989. Science. 246, 497-500.
Sato etal. 1984, The Lancet (Jan. 21, 1984) pp. 122-126.
Nencioni etal. 1991. Infection and Immunity 59, 625-630.

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