Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1998-11-17
2000-02-22
Stucker, Jeffrey
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241841, 4242341, 4242361, 4242781, 4242821, A01N 3718
Patent
active
060277319
ABSTRACT:
A therapeutic remodeling of immune system for HIV evaluation and AIDS treatment. Specifically, the present invention involves eliciting lymphocytosis in order to reveal the sequestered HIV or SIV in the lymph tissues enabling HIV infection analysis, viral quantification and treatment. The lymphocytosis itself causes an alleviation of the AIDS symptoms and a reduction in the viral load. The present invention could also be used in conjunction with a large variety of adjunct therapies.
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Person et al., "Pertussis Toxin-Induced Lymphocytosis is Associated with Alterations in Thymocyte Subpopulations," Journal of Immunology, vol. 148, No. 5 (Mar. 1, 1992), pp. 1506-1511.
Pauza et al, "SIV Transmission Across the Mucosal Barrier," AIDS Research and Human Retroviruses, vol. 10, Supp. 1, 1994, Mary Ann Liebert, Inc. Publishers.
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Pauza et al, "Pathogenesis of SIV.sub.mac251 After Atraumatic Inoculation of the Rectal Mucosa in Rhesus Monkeys," J. Med. Primatol, 22, pp. 154-161, 1993.
Pauza, "Acquired Resistance to Mucosal SIV Infection After Low Dose Intrarectal Inoculation: The Roles of Virus Selection and CD8-Mediated T Cell Immunity," Huitieme Colloque Des Cent Gardes, pp. 151-156, 1993.
Pauza, "Transmission of SIV by Intrarectal Inoculation in Rhesus Monkeys," Septieme Colloque Des Cent Gardes, pp. 69-74, 1992.
Trivedi et al, "Selective Amplification of Simian Immunodeficiency Virus Genotypes After Intrarectal Inoculation of Rhesus Monkeys," Journal of Virology, vol. 68, No. 11, pp. 7649-7653, Nov., 1994.
Stucker Jeffrey
Wisconsin Alumni Research Foundation
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