Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Patent
1994-06-17
1995-06-27
Patterson, Jr., Charles L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
4242401, 4242541, 514 12, A61K 3910
Patent
active
054277884
ABSTRACT:
Cloning and sequencing of the Eco RI fragment of B. pertussis chromosomal DNA with 4696 base pairs, containing the genes which code for the five subunits of the pertussis toxin.
A hybrid plasmid containing the DNA fragment or its further fragments and a micro-organism transformed by the hybrid plasmid and capable of expressing the cloned DNA fragment or further fragments thereof by synthesis of the pertussis toxin or one or more subunits of the pertussis toxin.
The pertussis toxin or one or more subunits of the pertussis toxin so obtained are useful for the preparation of vaccines and diagnostic kits.
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Hewlett et al. (1983) "Infection & Immunity," vol. 40, No. 3, pp. 1198-1203.
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Nicosia et al. (1986) Proc. Nat. Acad. Sci., vol. 83, pp. 4631-4635.
Arico' Maria B.
Nicosia Alfredo
Rappuoli Rino
McClung Barbara G.
Paintin Francis A.
Patterson Jr. Charles L.
Sclavo S.p.A.
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