Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Web – sheet or filament bases; compositions of bandages; or...
Patent
1997-10-23
1999-12-21
Clardy, S. Mark
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Web, sheet or filament bases; compositions of bandages; or...
424443, 424444, 424447, 424449, 514946, 514947, A61F 1302
Patent
active
060045787
ABSTRACT:
The present invention is directed to the transdermal administration of at least one drug together with a suitable amount of a permeation enhancer comprising monoalkyl ethers of polyethyleneglycol and their alkyl or aryl carboxylic acid esters and carboxymethyl ethers. The invention includes a transdermal drug delivery device comprising a matrix adapted to be placed in drug- and- permeation enhancer- transmitting relation with a skin site. The matrix contains sufficient amounts of the permeation enhancer and drug, in combination, to continuously administer drug to the systemic circulation of a patient at a therapeutically effective rate. The invention is also directed to compositions and methods for transdermal administration of at least one drug together with a permeation enhancer of this invention, alone or in combination with other enhancers.
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Williams, A.C., et al., Critical Reviews in Therapeutic Drug Carrier Systems, 9 (3,4), pp. 305-353 (1992), "Skin Absorption Enhancers".
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Lee Eun Soo
Yum Su II
ALZA Corporation
Clardy S. Mark
Rafa Michael J.
Stone Steven F.
Williamson Michael A.
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