Permeation enhancer compositions for increased absorption of the

Details Permeation enhancer compositions for increased absorption of the Permeation enhancer compositions for increased absorption of the

1995-06-05

1998-10-06

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514730, 514806, A61K 3827, A61K 3828, A61K 3104

Patent

active

058176241

ABSTRACT:
The present invention is directed to a pharmaceutical formulation of a therapeutic polypeptide together with a permeation-enhancing mixture of sodium 3-nitrobenzoate and an oil to provide enhanced absorption of the polypeptide through the wall of the gastrointestinal tract, and particularly of the colon, after oral administration.

REFERENCES:
patent: 5424289 (1995-06-01), Yang et al.
Nishinata et al., Biochem. et Biophysica Acta vol. 775 (1984) pp. 269-271.
Goodman & Gilman's "The Pharmacological Basis of Therapeutics" 6th Ed. (MacMillan Publishing Co. Inc 1980) pp. 5-7.
Chemial Abstract, vol. 106, No. 8, 23 Feb. 1987, Columbus, Ohio, US; Abstract No. 55786.
Int. J. Pharm., vol. 34, No. 1-2, 1986, pp. 35-43; J.A. Moore et al., "Absorption Enhancement of Growth Hormone from the Gastrointestinal Tract of Rats".

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